Characterisation of chicken ZAP
Characterisation of chicken ZAP
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DOI：
10.1016/j.dci.2014.05.011
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发表时间：
2014-10-01
影响因子：
2.9
通讯作者：
Bean, Andrew G. D.
中科院分区：
文献类型：
--
作者：
Goossens, Kate E.;Karpala, Adam J.;Bean, Andrew G. D.
新出现的致病性病毒，如禽流感（A1），对家禽业和人类健康构成严重威胁。开发新的治疗方法来预防这些病毒是至关重要的，需要了解宿主免疫机制，以找到新的途径来预防病毒感染。干扰素（IFN）是免疫系统的主要抗病毒武器，通常是抵抗病毒的第一道防线。由于缺乏试剂和研究工作，由IFN上调协调的多个基因在鸡中没有得到很好的表征。在这里，我们已经确定了鸡ZAP（chZAP），IFN刺激基因（ISG），在人类模型中具有抗病毒特性，并显示chZAP在PAMP反应中上调。此外，我们表明，chZAP在体内特定的病毒感染后上调。这些数据将有助于进一步研究，旨在了解鸡的抗病毒反应途径。皇冠版权所有（C）2014由爱思唯尔有限公司出版。保留所有权利。
Emerging pathogenic viruses, such as avian influenza (Al), represent a serious threat to the poultry industry and human health. The development of novel therapeutics to protect against these viruses is critical and necessitates understanding the host immune mechanisms to find new pathways for protection against virus infection. Interferon (IFN) is a major antiviral arm of the immune system and is generally the first line of defence against virus. The multiple genes orchestrated by IFN upregulation are not well characterised in chickens due to a lack of reagents and research efforts. Here we have identified chicken ZAP (chZAP), an IFN stimulated gene (ISG), that has antiviral properties in human models, and show that chZAP is upregulated in response to PAMPs. Moreover, we show that chZAP is upregulated in vivo following particular viral infections. This data will benefit further studies that aim to understand antiviral response pathways in the chicken. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.