Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin
Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin
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DOI：
10.1101/cshperspect.a021642
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发表时间：
2017-12-01
影响因子：
7.2
通讯作者：
Capetanaki, Yassemi
中科院分区：
文献类型：
--
作者：
Hol, Elly M.;Capetanaki, Yassemi
III型中间丝（IF）蛋白与其他III型和一些IV型IF组装成细胞质均聚和杂聚丝。这些高度动态的结构形成肌肉、脑和间充质细胞的细胞骨架的组成部分。在这里，我们回顾了目前的想法在健康和疾病的III型IF的作用。事实证明，它们不仅提供了对机械应变的弹性，而且最重要的是，它们非常有效地促进了细胞结构和功能的整合，从而为生化应激时的最佳细胞反应提供了必要的支架，并保护细胞免受死亡，疾病和衰老。
Type III intermediate filament (IF) proteins assemble into cytoplasmic homopolymeric and heteropolymeric filaments with other type III and some type IV IFs. These highly dynamic structures form an integral component of the cytoskeleton of muscle, brain, and mesenchymal cells. Here, we review the current ideas on the role of type III IFs in health and disease. It turns out that they not only offer resilience to mechanical strains, but, most importantly, they facilitate very efficiently the integration of cell structure and function, thus providing the necessary scaffolds for optimal cellular responses upon biochemical stresses and protecting against cell death, disease, and aging.