Diversity in the bone marrow niche: Classic and novel strategies to uncover niche composition.
Diversity in the bone marrow niche: Classic and novel strategies to uncover niche composition.
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DOI：
10.1111/bjh.18355
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发表时间：
2022-12
影响因子：
6.5
通讯作者：
Ganuza, Miguel
中科院分区：
文献类型：
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作者：
Sanchez-Lanzas, Raul;Kalampalika, Foteini;Ganuza, Miguel
关键词：
随着时间的推移，我们对骨髓（BM）的作用和组成的看法发生了巨大的变化，从骨骼的简单营养物质到维持造血的高度复杂的多细胞组织。在这些细胞中，多能造血干细胞（hsc）主要处于静止状态，具有独特的自我更新能力和多谱系分化潜力，并补充所有血液谱系以维持终身造血。成人造血干细胞存在于专门的骨髓壁龛中，这支持了它们的功能。由于其潜在的临床相关性，已经投入了大量的努力来破译HSC小生境。多种细胞类型涉及HSC -生态位成分，包括窦内皮细胞、血管周围基质细胞、巨噬细胞、巨核细胞、成骨细胞和交感神经。在这篇综述中，我们从历史的角度提供了技术进步，从遗传小鼠模型到成像和高通量测序技术，揭示了塑造生态位和调节HSC功能的大量分子线索和细胞成分。
Our view on the role and composition of the bone marrow (BM) has dramatically changed over time from a simple nutrient for the bone to a highly complex multicellular tissue that sustains haematopoiesis. Among these cells, multipotent haematopoietic stem cells (HSCs), which are predominantly quiescent, possess unique self‐renewal capacity and multilineage differentiation potential and replenish all blood lineages to maintain lifelong haematopoiesis. Adult HSCs reside in specialised BM niches, which support their functions. Much effort has been put into deciphering HSC niches due to their potential clinical relevance. Multiple cell types have been implicated as HSC‐niche components including sinusoidal endothelium, perivascular stromal cells, macrophages, megakaryocytes, osteoblasts and sympathetic nerves. In this review we provide a historical perspective on how technical advances, from genetic mouse models to imaging and high‐throughput sequencing techniques, are unveiling the plethora of molecular cues and cellular components that shape the niche and regulate HSC functions.
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影响因子：
23.9
作者：
Butler JM;Nolan DJ;Vertes EL;Varnum-Finney B;Kobayashi H;Hooper AT;Seandel M;Shido K;White IA;Kobayashi M;Witte L;May C;Shawber C;Kimura Y;Kitajewski J;Rosenwaks Z;Bernstein ID;Rafii S
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Rafii S
影响因子：
64.5
作者：
Baryawno, Ninib;Przybylski, Dariusz;Scadden, David T.
通讯作者：
Scadden, David T.
影响因子：
21.3
作者：
Asada N;Kunisaki Y;Pierce H;Wang Z;Fernandez NF;Birbrair A;Ma'ayan A;Frenette PS
通讯作者：
Frenette PS
影响因子：
64.8
作者：
Chen JY;Miyanishi M;Wang SK;Yamazaki S;Sinha R;Kao KS;Seita J;Sahoo D;Nakauchi H;Weissman IL
通讯作者：
Weissman IL
影响因子：
82.9
作者：
通讯作者：
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