The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury
The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury
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DOI：
10.1073/pnas.040469797
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发表时间：
2000-02-29
影响因子：
11.1
通讯作者：
Korneluk, RG
中科院分区：
文献类型：
--
作者：
Holcik, M;Thompson, CS;Korneluk, RG
神经元凋亡抑制蛋白（NAIP）是一个新的凋亡抑制蛋白家族成员。IAP基因从杆状病毒到后生动物高度保守，并在体外和体内抑制由多种触发物诱导的细胞凋亡。在这里，我们描述了与NAIP 1的靶向删除小鼠的产生和表征，我们证明，NAIP 1-删除小鼠发育正常。然而，在NAIP 1基因敲除动物中，海人酸诱导的边缘癫痫发作后海马锥体神经元的存活率大大降低。因此，尽管NAIP 1对于小鼠中枢神经系统的正常发育不是必需的，但是内源性NAIP 1对于病理条件下的神经元存活是必需的。
The neuronal apoptosis inhibitory protein (NAIP) is a member of a novel family of inhibitor of apoptosis (IAP) proteins. The IAP genes are highly conserved from baculovirus to metazoans and suppress apoptosis induced by a variety of triggers both in vitro and in vivo. Here we describe the generation and characterization of mice with the targeted deletion of NAIP1, We demonstrate that the NAIP1-deleted mice develop normally. However, the survival of pyramidal neurons in the hippocampus after kainic acid-induced limbic seizures is greatly reduced in the NAIP1 knock-out animals. Thus, although NAIP1 is not necessary for normal development of murine central nervous system, the endogenous NAIP1 is required for neuronal survival in pathological conditions.