Dynamic changes of cerebral oxygenation measured by brain tissue oxygen pressure and near infrared spectroscopy
Dynamic changes of cerebral oxygenation measured by brain tissue oxygen pressure and near infrared spectroscopy
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DOI：
10.1080/01616412.1997.11740807
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发表时间：
1997-06-01
影响因子：
1.9
通讯作者：
Brawanski, A
中科院分区：
文献类型：
--
作者：
Holzschuh, M;Woertgen, C;Brawanski, A
本研究旨在探讨近红外光谱测量脑组织氧压（ti-pO(2)）与血红蛋白氧合（HbO(2)）变化之间是否存在相关性。我们研究了10例严重颅脑损伤患者。给药后尽快在额叶白质中植入ti-pO(2)监测装置。此外，在前额放置了一个近红外传感器。同时记录AN数据。ti-pO(2)曲线的变化被定义为具有以下标准的事件：>比基线值变化10%，>持续时间3分钟，显然不是伪影。137个事件中，ti-pO(2)的平均变化为8.3 +/- 10.2 mmHg。77.4%的患者观察到相应的HbO变化(2)。在7例患者中，我们发现改变ti-pO(2)与改变HbO(2)之间有良好的相关性（r >.7）。其中3例相关性较差。相关性差的原因可能是近红外传感器信号质量差或全脑缺血区域分布不均匀。我们认为，在近红外光谱信号稳定和脑弥漫性病变的情况下，近红外光谱能很好地反映ti-pO(2)的变化。
The aim of this study was to find out whether a correlation exists between changes in brain tissue oxygen pressure (ti-pO(2)) and hemoglobin oxygenation (HbO(2)) measured by near-infrared spectroscopy. We studied 10 patients with severe head injury. A ti-pO(2) monitoring device was introduced in the frontal white matter as soon as possible after administration. Additionally a NIRS sensor was placed at the forehead. AN data were recorded simultaneously. Changes of the ti-pO(2) curve were defined as events with the following criteria: > 10% change from the baseline value, > 3 min duration, clearly not an artifact. 137 events were found with a mean change of ti-pO(2) of 8.3 +/- 10.2 mmHg. In 77.4% we observed a corresponding change of the HbO(2). In 7 patients we found a good correlation (r>0.7) between change ti-pO(2) and change HbO(2). In 3 patients the correlation was poor. The reason for poor correlation might be poor signal quality of the NIRS sensor or inhomogenous distribution of ischemic areas in the whole brain. We conclude that under the condition of a stable NIRS signal and a diffuse brain lesion, changes of ti-pO(2) are well reflected by NIRS.