Asymmetric Michael additions of aldehydes to maleimides using a recyclable fluorous thiourea organocatalyst
Asymmetric Michael additions of aldehydes to maleimides using a recyclable fluorous thiourea organocatalyst
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DOI：
10.1016/j.tetlet.2011.05.145
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发表时间：
2011-08-10
影响因子：
1.8
通讯作者：
Itoh, Akichika
中科院分区：
文献类型：
--
作者：
Miura, Tsuyoshi;Nishida, Shohei;Itoh, Akichika
含氟硫脲有机催化剂3促进了醛与马来酰亚胺的Michael反应，以高产率得到相应的加合物，ee高达99%。通过简单的过滤，氟有机催化剂3可以很容易地从反应混合物中以不溶沉淀物的形式回收，并且可以重复使用，而不会造成明显的催化活性损失。(C)2011爱思唯尔有限公司。保留所有权利。
Fluorous thiourea organocatalyst 3 promotes the Michael reaction of aldehydes with maleimides to afford the corresponding adducts in high yields with up to 99% ee. Fluorous organocatalyst 3 can be easily recovered as an insoluble precipitate from the reaction mixture by simple filtration and can be reused without significant loss of catalytic activity. (C) 2011 Elsevier Ltd. All rights reserved.