Helix-packing motifs in membrane proteins
Helix-packing motifs in membrane proteins
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DOI：
10.1073/pnas.0605878103
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发表时间：
2006-09-12
影响因子：
11.1
通讯作者：
DeGrado, W. F.
中科院分区：
文献类型：
--
作者：
Walters, R. F. S.;DeGrado, W. F.
螺旋膜蛋白的折叠在很大程度上是由嵌入膜的螺旋之间的相互作用决定的。为了阐明反复出现的螺旋-螺旋相互作用基序，我们将膜蛋白的晶体结构分解为相互作用的螺旋对库。根据它们的三维相似性（rmsd）对它们进行聚类
The fold of a helical membrane protein is largely determined by interactions between membrane-imbedded helices. To elucidate recurring helix-helix interaction motifs, we dissected the crystallographic structures of membrane proteins into a library of interacting helical pairs. The pairs were clustered according to their three-dimensional similarity (rmsd