ORGANIZATION OF HAEMOPOIETIC STEM CELLS: THE GENERATION‐AGE HYPOTHESIS
ORGANIZATION OF HAEMOPOIETIC STEM CELLS: THE GENERATION‐AGE HYPOTHESIS
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造血干细胞的组织：世代假说
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
T. R. Bradley
中科院分区：
文献类型：
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作者：
Martin Rosendaal;G. Hodgson;T. R. Bradley
本文提出，以前的分裂历史的每个干细胞是一个决定因素的功能组织的造血干细胞群体。在动物中，来自产生许多干细胞的干细胞谱系的干细胞（较老的干细胞）在产生很少干细胞的干细胞（较年轻的干细胞）之前用于形成血液。干细胞谱系的干细胞生成能力是有限的。在给定数量的世代之后，干细胞通过形成细胞系的两个定向前体而丢失到干细胞区室。它在血液形成中的作用由下一个最古老的干细胞承担。我们把这个假设称为世代假说。
This paper proposes that the previous division history of each stem cell is one determinant of the functional organization of the haemopoietic stem cell population. Stem cells from a lineage of stem cells which have generated many stem cells (older stem cells) are used in the animal to form blood before stem cells which have generated few stem cells (younger stem cells). The stem cell generating capacity of a lineage of stem cells is finite. After a given number of generations a stem cell is lost to the stem cell compartment by forming two committed precursors of the cell lines. Its part in blood formation is taken by the next oldest stem cell. We have called this proposal the generation‐age hypothesis.