Effects of triamcinolone acetonide on an in vivo equine osteochondral fragment exercise model
Effects of triamcinolone acetonide on an in vivo equine osteochondral fragment exercise model
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DOI：
10.1111/j.2042-3306.1997.tb03138.x
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发表时间：
1997-09-01
影响因子：
2.2
通讯作者：
McIlwraith, CW
中科院分区：
文献类型：
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作者：
Frisbie, DD;Kawcak, CE;McIlwraith, CW
为探讨关节内注射曲安奈德(TA)对运动马运动员腕骨骨软骨碎裂的治疗效果，将18匹马随机分为3组，每匹马随机选择1个腕间关节制作骨软骨碎片，安慰剂对照组(CNT)两侧腕间关节内注射聚离子液体(IA)，TA对照组(CTA CNT)两侧关节内注射TA 12 mg，对侧腕间关节注射相同体积的聚离子液体。TA治疗组(TA TX)在含有骨软骨碎片的关节处注射TA 12 mg，对侧腕间关节注射等量的聚离子液体。所有马于术后第13天和第27天接受IA治疗，并从第14天开始在高速跑步机上运动6周。与CNT组和TA CNT组相比，TA TX组的跛行程度明显减轻，而TA CNT组和TA TX组的关节液中总蛋白含量低于CNT组，关节液中透明质酸和糖胺多糖浓度高于CNT组。与CNT组相比，TA CNT和TA TX组的滑膜炎性细胞浸润、内膜下增生和内膜下纤维化明显减少，关节软骨的组织形态参数明显好于CNT组。结论，本研究结果支持TA对临床可检测到的跛行程度、滑液、滑膜和关节软骨形态参数的有利影响，与安慰剂治疗相比，关节内直接给药和远程给药都是如此。IA给药在马身上的临床应用可能对选定的骨软骨碎裂和骨关节炎病例有治疗上的好处。
The objective of this study was to determine the effects of intra-articularly administered triamcinolone acetonide (TA) in exercised equine athletes with carpal osteochondral fragmentation, Eighteen horses were randomly assigned to each of 3 groups, An osteochondral chip fragment was created in one randomly chosen intercarpal joint of each horse, Both intercarpal joints in the placebo control group (CNT) horses were injected with intra-articular administration (IA) of polyionic fluid, Both joints in the TA control group (CTA CNT) horses were treated with 12 mg of TA in the intercarpal joint without an osteochondral fragment, and the opposite intercarpal joint was injected with a similar volume of polyionic fluid. The TA treated group (TA TX) horses were treated with 12 mg of TA in the joint that contained the osteochondral fragment and the opposite intercarpal joint was injected with a similar volume of polyionic fluid. All horses were treated IA on days 13 and 27 after surgery and exercised on a high speed treadmill for 6 weeks starting on Day 14.Horses in the TA TX group were significantly less lame than horses in the CNT and TA CNT groups, Horses in either TA CNT or TA TX groups had lower total protein, and higher hyaluronan, and glycosaminoglycan concentrations in synovial fluid than did those in the CNT group. Synovial membrane collected from subjects in TA CNT and TA TX groups had significantly less inflammatory cell infiltration, subintimal hyperplasia and subintimal fibrosis compared to the CNT group, Articular cartilage histomorphological parameters were significantly better from the TA CNT and TA TX groups compared to the CNT group,In conclusions, results from this study support favourable effects of TA on degree of clinically detectable lameness, and on synovial fluid, synovial membrane, and articular cartilage morphological parameters, both with direct intra-articular administration and remote site administration as compared to placebo treatment. The clinical use of IA administered TA in horses may be therapeutically beneficial in selected cases of osteochondral fragmentation and osteoarthritis.