Relation of Framingham risk score to subclinical atherosclerosis evaluated across three arterial sites
Relation of Framingham risk score to subclinical atherosclerosis evaluated across three arterial sites
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DOI：
10.1016/j.amjcard.2008.05.039
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发表时间：
2008-10-01
影响因子：
2.8
通讯作者：
Mack, Wendy J.
中科院分区：
文献类型：
--
作者：
Karim, Roksana;Hodis, Howard N.;Mack, Wendy J.
弗雷明汉风险评分（FRS）广泛应用于临床实践中，以识别罹患冠心病的高风险受试者。然而，FRS 可能无法准确识别处于危险中的受试者。我们通过 498 名健康受试者的内膜中层厚度测量了存在钙的冠状动脉和主动脉以及颈总动脉的亚临床动脉粥样硬化。这些亚临床动脉粥样硬化指标的分布在 FRS 的 3 层中进行了评估。冠状动脉是否存在钙、主动脉是否存在钙以及颈动脉的内膜中层厚度与 FRS 显着独立相关。 FRS随着动脉粥样硬化部位数量的增加而增加； 69% 的低风险组 (FRS 10%)、95% 的中度风险组 (FRS 10% 至 20%) 和 100% 的高风险组 (FRS >20%) 受试者有 >= 1 项血管成像研究显示亚临床动脉粥样硬化。在低风险组中，患有动脉粥样硬化的受试者比没有动脉粥样硬化的受试者有更长的终生吸烟史。总之，亚临床动脉粥样硬化在整个 FRS 谱系中都很突出。除了 FRS 之外，对不同动脉部位的亚临床动脉粥样硬化进行评估可能有助于针对受试者进行生活方式和其他干预措施。 (C) 2008 Elsevier Inc. 保留所有权利。
The Framingham risk score (FRS) is widely used in clinical practice to identify subjects at high risk for developing coronary heart disease. However, FRS may not accurately identify subjects at risk. We measured subclinical atherosclerosis in the coronary arteries and aorta with the presence of calcium and in the common carotid artery by intima-media thickness in 498 healthy subjects. The distribution of these subclinical atherosclerosis measures was evaluated across 3 strata of the FRS. Coronary arteries with the presence of calcium, aorta with the presence of calcium, and carotid artery by intima-media thickness were significantly independently associated with FRS. The FRS increased with the number of arterial sites with atherosclerosis; 69% of the subjects categorized in the low risk group (FRS 10%), 95% of the intermediate risk group (FRS 10% to 20%), and 100% of the high risk group (FRS >20%) had >= 1 vascular imaging studies demonstrating subclinical atherosclerosis. In the low risk group, subjects with atherosclerosis had a longer history of lifetime smoking compared with those without atherosclerosis. In conclusion, subclinical atherosclerosis is prominent across the spectrum of FRS. Evaluation of subclinical atherosclerosis in different arterial sites in addition to FRS may be useful in targeting subjects for lifestyle and other interventions. (C) 2008 Elsevier Inc. All rights reserved.