Arterial Stiffness, Kidney Function, and Chronic Kidney Disease Progression.
Arterial Stiffness, Kidney Function, and Chronic Kidney Disease Progression.
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DOI：
10.1159/000354113
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发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Tomiyama H
中科院分区：
文献类型：
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作者：
Townsend RR;Tomiyama H
如今，可以在地球仪周围轻松且无创地测量动脉硬度。尽管已被公认为心血管事件的独立预测因子，但对动脉僵硬度在慢性肾脏病（CKD）发生后肾功能进行性丧失中的作用知之甚少。除了测量动脉硬度之外，现在许多设备可以无创地记录来自诸如桡动脉等部位的脉搏曲线，并且使用内部算法能够估计中心压力曲线。尽管这些设备已经生成了大量关于心血管事件预测的数据，例如动脉硬度的测量，但是关于这些测量在CKD进展中的预测效用知之甚少。在这篇综述中，我们涵盖了通过脉搏波速度测量动脉硬度的方法，并讨论了脉搏波形的收缩和舒张轮廓的测量，维斯它们与肾功能随时间下降的关系。我们将我们的覆盖范围限制在具有纵向数据的研究上，但我们也包括一个研究表，据我们所知，这些研究目前只发表了横截面数据。
Arterial stiffness can nowadays be measured easily and noninvasively around the globe. Although well established as an independent predictor of cardiovascular events, less is known about the role of arterial stiffness in the progressive loss of kidney function once chronic kidney disease (CKD) is established. In addition to measures of arterial stiffness, a number of devices now noninvasively record the pulse profile from sites such as the radial artery and, using internal algorithms, are able to estimate central pressure profiles. Although these devices have generated much data on the prediction of cardiovascular events, e.g. measures of arterial stiffness, there is much less known about the predictive utility of these measures in CKD progression. In this review, we cover approaches to arterial stiffness as measured by pulse wave velocity and discuss measures of the systolic and diastolic contour of the pulse waveform vis-à-vis their relationship to declines in kidney function over time. We restrict our coverage to studies that have longitudinal data, but we also include a table of studies, which, to our knowledge, have only published cross-sectional data at this time.