Diffusion-tensor MR imaging of intracranial neoplasia and associated peritumoral edema: Introduction of the tumor infiltration index
Diffusion-tensor MR imaging of intracranial neoplasia and associated peritumoral edema: Introduction of the tumor infiltration index
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DOI：
10.1148/radiol.2321030653
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发表时间：
2004-07-01
期刊：
影响因子：
19.7
通讯作者：
Grossman, RI
中科院分区：
文献类型：
--
作者：
Lu, S;Ahn, D;Grossman, RI
目得：确定瘤周水肿的弥散张量磁共振（MR）成像指标是否可用于区分轴内和轴外病变、胶质瘤转移病变以及高级别和低级别胶质瘤。材料和方法：在这项研究中，弥散张量磁共振成像进行了术前40例颅内肿瘤，包括脑膜瘤，转移性病变，多形性胶质母细胞瘤，低级别胶质瘤。平均扩散率（MD）和各向异性分数（FA）的直方图被用来分析肿瘤和相关的T2信号强度异常。另外一个指标，肿瘤浸润指数（TII），进行了评价。TII是FA变化的量度，推测由肿瘤细胞浸润瘤周水肿引起。Student t检验和最小二乘线性回归分析performed.RESULTS：瘤周MD和FA值表示内和轴外病变之间或高级别和低级别胶质瘤之间没有统计学显著差异。对于轴内肿瘤，测量的转移性病变的平均瘤周MD为0.733 x 10（-3）mm（2）/sec +/- 0.061（SD），显著高于胶质瘤的平均瘤周MD 0.587 +/- 0.093 x 10（-3）mm（2）/sec（P <0.05）。脑膜瘤和转移瘤周围水肿的TIIs（平均0 ± 35）和胶质瘤周围水肿的TIIs（平均64 ± 59）之间也有统计学显著差异（P <0.05）。结论：瘤周弥散张量MR成像指标能够区分孤立性轴内转移性脑肿瘤和胶质瘤。此外，TII能够区分假定的肿瘤浸润性水肿和纯粹的血管源性水肿。(C)RSNA，2004年。
PURPOSE: To determine whether diffusion-tensor magnetic resonance (MR) imaging metrics of peritumoral edema can be used to differentiate intra- from extraaxial lesions, metastatic lesions from gliomas, and high- from low-grade gliomas.MATERIALS AND METHODS: In this study, diffusion-tensor MR imaging was performed preoperatively in 40 patients with intracranial neoplasms, including meningiomas, metastatic lesions, glioblastomas multiforme, and low-grade gliomas. Histograms of mean diffusivity (MD) and fractional anisotropy (FA) were used to analyze both the tumor and the associated T2 signal intensity abnormality. An additional metric, the tumor infiltration index (TII), was evaluated. The TII is a measure of the change in FA presumably caused by tumor cells infiltrating the peritumoral edema. Student t test and least-squares linear regression analyses were performed.RESULTS: Peritumoral MD and FA values indicated no statistically significant difference between intra- and extraaxial lesions or between high- and low-grade gliomas. Regarding intraaxial tumors, the measured mean peritumoral MD of metastatic lesions, 0.733 x 10(-3) mm(2)/sec +/- 0.061 (SD), was significantly higher than that of gliomas, 0.587 +/- 0.093 x 10(-3) mm(2)/sec (P < .05). There was also a statistically significant difference between the TIIs of the edema surrounding meningiomas and metastases (mean, 0 +/- 35) and the TIIs of the edema surrounding gliomas (mean, 64 +/- 59) (P < .05).CONCLUSION: Peritumoral diffusion-tensor MR imaging metrics enable the differentiation of solitary intraaxial metastatic brain tumors from gliomas. in addition, the TII enables one to distinguish presumed tumor-infiltrated edema from purely vasogenic edema. (C) RSNA, 2004.