Combined pathological effects of cocaine abuse and HIV infection on the cardiovascular system: an autopsy study of 187 cases from the Fulton County Medical Examiner's office.
Combined pathological effects of cocaine abuse and HIV infection on the cardiovascular system: an autopsy study of 187 cases from the Fulton County Medical Examiner's office.
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可卡因滥用和 HIV 感染对心血管系统的综合病理影响：对富尔顿县法医办公室 187 例病例进行的尸检研究。
DOI：
10.1097/paf.0b013e318165152f
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Mosunjac,MarinaB
中科院分区：
文献类型：
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作者：
Mosunjac,MarioI;Sundstrom,JBruce;Heninger,Michael;Ansari,AftabA;Mosunjac,MarinaB
这项尸检研究评估了感染艾滋病毒的成年人使用可卡因对心血管组织的可能累积影响。本文共复习了187例尸检病例报告及心肌和冠状动脉的H&E切片。定义了四个主要研究组：（A）共63例可卡因阳性和HIV阴性（COC）;（B）40例HIV/AIDS阳性和可卡因阴性（HIV）;（C）23例HIV/AIDS和可卡因（HIV/COC）;（D）61例年龄、性别和种族匹配的对照组，可卡因和HIV阴性（CONT）。分析了以下形态学和人口统计学数据：心脏重量、左心室肥大、心肌纤维化、心肌内血管增厚、心肌炎、急性或陈旧性心肌梗死（MI）、年龄、性别和种族。HIV/COC组中冠状动脉壁和外膜浸润、心肌炎和心肌内血管增厚的频率增加（14.5%、17.4%和17.4% vs. CONT组中的6.5%、3.3%和0%）可能表明HIV和可卡因对心血管病理学可能具有联合和/或累积效应。
This autopsy study evaluates the possible cumulative effects of cocaine use in HIV-infected adult individuals on cardiovascular tissue. A total of 187 autopsy case reports and available H&E sections of myocardium and coronary arteries were reviewed. Four major study groups were defined:(A) a total of 63 cases positive for cocaine and negative for HIV (COC);(B) 40 cases positive for HIV/AIDS and negative for cocaine (HIV),(C) 23 cases both HIV/AIDS and cocaine (HIV/COC), and (D) a control group of 61 age-, sex-and race-matched, negative for cocaine and for HIV (CONT). The following morphologic and demographic data were analyzed: heart weight, left ventricular hypertrophy, myocardial fibrosis, thickening of the intramyocardial vessels, myocarditis, acute or remote myocardial infarcts (MI), age, sex, and race. Increased frequency of coronary wall and adventitial infiltrates, myocarditis, and thickened intramyocardial vessels present in HIV/COC group (14.5%, 17.4%, and 17.4% vs. 6.5%, 3.3%, and 0% in CONT group) may indicate possible combined and/or cumulative effects of HIV and cocaine on cardiovascular pathology.