Herpesvirus saimiri-encoded proteins Tip and StpC modulate human immunodeficiency virus type 1 replication in T-cell lines and lymphocytes independently of viral tropism.
Herpesvirus saimiri-encoded proteins Tip and StpC modulate human immunodeficiency virus type 1 replication in T-cell lines and lymphocytes independently of viral tropism.
复制标题
疱疹病毒 saimiri 编码蛋白 Tip 和 StpC 独立于病毒向性调节 T 细胞系和淋巴细胞中的人类免疫缺陷病毒 1 型复制。
DOI：
10.1016/j.virol.2004.03.021
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Henderson,EarlE
中科院分区：
文献类型：
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作者：
Raymond,AndreaD;Hasham,MuneerG;Tsygankov,AlexanderY;Henderson,EarlE
松鼠猴疱疹病毒（HVS）转化的T淋巴细胞对1型人类免疫缺陷病毒（HIV-1）的X4和R5毒株都是允许的。HVS编码的蛋白质酪氨酸激酶相互作用蛋白（Tip）和saimiri转化相关蛋白C亚群（StpC）先前与改变HIV容许性有关。表达StpC或StpC和Tip的MOLT 4细胞允许HIV-1的X4毒株。相反，HIV-1仅限于表达Tip的MOLT 4细胞。在这里，我们表明，MOLT 4细胞和原代淋巴细胞表达StpC是允许的R5株的HIV-1，而提示表达限制R5株。这些结果表明，用Tip和StpC进行的细胞内免疫可以被开发为针对HIV-1的X4和R5毒株的治疗策略的模型。
Herpesvirus saimiri (HVS)-transformed T-lymphocytes are permissive for both X4 and R5 strains of human immunodeficiency virus type 1 (HIV-1). HVS-encoded proteins tyrosine-kinase interacting protein (Tip) and saimiri transformation-associated protein subgroup C (StpC) were previously implicated in altering HIV permissiveness. MOLT4 cells expressing StpC or StpC and Tip are permissive for X4 strains of HIV-1. In contrast, HIV-1 was restricted in MOLT4 cells expressing Tip alone. Here we show that MOLT4 cells and primary lymphocytes expressing StpC are permissive for R5 strains of HIV-1 while Tip expression restricted R5 strains. These results suggest that intracellular immunization with Tip and StpC could be developed as models for therapeutic strategies targeting both X4 and R5 strains of HIV-1.