ROLE OF 5-HYDROXYTRYPTAMINE IN KETAMINE-INDUCED HYPOTHERMIA IN RAT
ROLE OF 5-HYDROXYTRYPTAMINE IN KETAMINE-INDUCED HYPOTHERMIA IN RAT
复制标题
DOI：
10.1111/j.1476-5381.1973.tb08243.x
复制
发表时间：
1973-01-01
影响因子：
7.3
通讯作者：
OSMAN, OH
中科院分区：
文献类型：
--
作者：
FAHIM, I;ISMAIL, M;OSMAN, OH
1.腹腔注射不同剂量的氯胺酮可引起大鼠体温下降，呈剂量依赖性。同样，脑内注射小得多的剂量会产生体温过低。2.对氯苯丙氨酸(PCPA)可显著减弱氯胺酮的降温反应，而腹腔注射5-羟色氨酸可恢复氯胺酮的降温作用。3.利血平耗竭脑单胺类物质可完全阻断氯胺酮所致的体温下降。然而，用二乙基二硫代氨基甲酸钠(DEDTC)处理并不改变氯胺酮的降温作用。4.帕吉林可增强氯胺酮的降温作用。5.利血平联合抑制去甲肾上腺素生物合成(DEDTC)可使脑内单胺类物质耗竭，导致体温持续下降，而氯胺酮对此无影响。6.当环境温度从26℃升高到32℃时，氯胺酮引起的体温降低，并叠加在所有动物都出现的体温升高上。结论：氯胺酮引起大鼠体温降低可能是通过下丘脑释放5-羟色胺实现的，这种作用在某些方面与吗啡对不耐受大鼠的作用相似。
1. Intraperitoneal injection of graded doses of ketamine produced a dose-dependent fall in body temperature of rats. Similarly, intracerebral injection of much smaller doses produced hypothermia. 2. Pretreatment of the rats with p-chlorophenylalanine (PCPA) greatly attenuated the hypothermic response to ketamine whereas the intraperitoneal injection of 5-hydroxytryptophan in PCPA-treated rats restored the hypothermic effect of ketamine. 3. Depletion of the brain monoamines by reserpine completely prevented the ketamine-induced hypothermia. Treatment with sodium diethyldithiocarbamate (DEDTC), however, did not modify the hypothermic effect of ketamine. 4. Pretreatment of the rats with pargyline potentiated the ketamine-induced hypothermia. 5. Depletion of brain monoamines by reserpine in combination with inhibition of noradrenaline biosynthesis (DEDTC) resulted in a long lasting fall in temperature which was not modified by ketamine. 6. When the ambient temperature was raised from 26° C to 32° C, ketamine-induced hypothermia was much reduced and superimposed on a hyperthermia which occurred in all animals. 7. It is concluded that ketamine produces hypothermia in rats possibly through the release of 5-hydroxytryptamine in the hypothalamus and that this effect is similar in some respects to that produced by morphine in non-tolerant rats.