Correlation between corneal sensitivity, subjective dry eye symptoms and corneal staining in Sjogren's syndrome
Correlation between corneal sensitivity, subjective dry eye symptoms and corneal staining in Sjogren's syndrome
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DOI：
10.1016/s0008-4182(04)80071-1
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发表时间：
2004-12-01
影响因子：
4.2
通讯作者：
Slomovic, A
中科院分区：
文献类型：
--
作者：
Adatia, FA;Michaeli-Cohen, A;Slomovic, A
背景：先前的研究表明干燥综合征患者的干眼症状和客观临床体征之间的相关性较差。我们研究的假设，减少角膜敏感性与增加眼表疾病和减少症状的患者与Sjogren's syndrome.Methods：18例诊断为Sjogren's syndrome参加了Sjogren's诊所参加了这项研究。所有参与者完成了眼表疾病指数（OSDI）和不适症状严重程度（SSD）量表，并回答了有关干眼症症状总体严重程度的问题。受试者接受最佳矫正的Snellen视力的测量，角膜敏感性测试与Cochet-Bonnet触觉仪，荧光素和丽丝胺绿色染色的角膜，Schirmer的测试I和泪膜破裂时间的测定。结果：角膜荧光素染色和丽丝胺绿色染色与角膜中央感觉呈负相关（r =-0.3542，p = 0.034; r =-0.3748，p = 0.029），说明角膜中央感觉随眼表疾病的加重而降低。总体症状严重程度与角膜丽丝胺绿色染色呈负相关（r =-0.4310，p = 0.011），提示症状减轻与角膜疾病增加相关。眼表疾病同样表现出与患者的干眼症症状的相互关系。因此，我们发现，与角膜染色较少的患者相比，具有晚期角膜染色的干燥综合征患者倾向于具有较少的干眼症状。
Background: Previous studies have shown a poor correlation between dry eye symptoms and objective clinical signs in patients with Sjogren's syndrome. We examined the hypothesis that reduced corneal sensitivity is associated with increased ocular surface disease and reduced symptoms in patients with Sjogren's syndrome.Methods: Eighteen subjects with a diagnosis of Sjogren's syndrome attending a Sjogren's clinic participated in the study. All participants completed the Ocular Surface Disease Index (OSDI) and the Symptom Severity of Discomfort (SSD) scale and answered a question regarding overall severity of dry eye symptoms. The subjects underwent measurement of best-corrected Snellen visual acuity, corneal sensitivity testing with the Cochet-Bonnet esthesiometer, fluorescein and lissamine green staining of the cornea, Schirmer's test I and determination of the tear film break-up time. The results were analysed using Pearson correlational analysis.Results: Both fluorescein and lissamine green staining of the cornea correlated negatively with central corneal sensation (r = -0.3542, p = 0.034, and r = -0.3748, p = 0.029 respectively), indicating that corneal sensation was reduced with increased ocular surface disease. The overall symptom severity correlated negatively with lissamine green staining of the cornea (r = -0.4310, p = 0.011), suggesting reduced symptoms with increased corneal disease.Interpretation: Reduced corneal sensation correlated with increased ocular surface disease. Ocular surface disease similarly demonstrated a reciprocal relation with patients' dry eye symptoms. Consequently, we found that patients with Sjogren's syndrome with advanced corneal staining tended to have fewer dry eye symptoms than patients with less corneal staining.