Cognitive Effects of Chemotherapy and Cancer-Related Treatments in Older Adults
Cognitive Effects of Chemotherapy and Cancer-Related Treatments in Older Adults
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DOI：
10.1016/j.jagp.2017.04.001
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发表时间：
2017-12-01
影响因子：
7.2
通讯作者：
Newhouse, Paul A.
中科院分区：
文献类型：
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作者：
Vega, Jennifer N.;Dumas, Julie;Newhouse, Paul A.
癌症治疗的进步正在产生越来越多的癌症幸存者;因此，癌症治疗期间和之后的生活质量问题变得越来越重要。化疗相关的认知障碍（CRCI）是癌症患者化疗后常见的问题。研究表明，CRCI可以在完成治疗后持续数月至数年，这对越来越多的长期癌症幸存者的正常和病理性认知老化的轨迹有影响。这些问题与老年人特别相关，因为癌症在很大程度上是一种老年疾病，65岁或以上的癌症患者人数将在未来几十年急剧增加。这篇综述将简要总结与CRCI相关的实证研究结果，讨论CRCI在老年癌症患者中的作用，提出潜在的致病假设，并提供一个典型的患者病例来说明CRCI在临床上的表现。最后，将强调CRCI的潜在干预策略，并讨论在评估有癌症史的老年患者时需要考虑的问题。
Advances in cancer treatment are producing a growing number of cancer survivors; therefore, issues surrounding quality of life during and following cancer treatment have become increasingly important. Chemotherapy-related cognitive impairment (CRCI) is a problem that is commonly reported following the administration of chemotherapy treatment in patients with cancer. Research suggests that CRCI can persist for months to years after completing treatment, which has implications for the trajectory of normal and pathologic cognitive aging for the growing number of long-term cancer survivors. These problems are particularly relevant for older individuals, given that cancer is largely a disease of older age, and the number of patients with cancer who are aged 65 years or older will increase dramatically over the coming decades. This review will briefly summarize empirical findings related to CRCI, discuss CRCI in older patients with cancer, propose potential causative hypotheses, and provide a canonical patient case to illustrate how CRCI presents clinically. Finally, potential intervention strategies for CRCI will be highlighted and issues to consider when evaluating older patients with a history of cancer will be discussed.