Maternal tolerance to H-Y is independent of IL-10
Maternal tolerance to H-Y is independent of IL-10
复制标题
DOI：
10.1081/imm-200032732
复制
发表时间：
2004-01-01
影响因子：
2.8
通讯作者：
Onyekwuluje, J
中科院分区：
文献类型：
--
作者：
Bonney, EA;Onyekwuluje, J
已经表明，母体免疫系统有利于非细胞毒性的“TH-2”免疫应答，以耐受发育中的胎儿。在某些品系的小鼠中，怀孕的雌性会拒绝雄性皮肤移植，即使它们容忍它们的雄性胎儿。这种排斥是基于对男性抗原H-Y的反应性。在这项研究中，我们测试男性胎儿的功能性母体耐受性是否严重依赖于TH-2细胞因子白细胞介素10（IL-10）。在与10-KO雄性交配前，通过腹膜内注射雄性脾细胞使正常和IL-10缺陷（10-KO）雌性对H-Y致敏。10-KO雌性所生的窝仔与相同遗传背景的正常雌性所生的窝仔大小相当。每窝雄性的比例未受到IL-10缺乏的不利影响。总之，我们的工作和其他人的工作表明，IL-10可能不是至关重要的母体耐受性的胎儿和扩展的证据反对的想法，成功的小鼠妊娠取决于TH-2偏差的母体免疫系统。
It has been suggested that the maternal immune system favors noncytotoxic, "TH-2" immune responses in order to tolerate the developing fetus. In some strains of mice, pregnant females will reject a male skin graft, even as they tolerate their male fetuses. This rejection is based on responsiveness to the male antigen H-Y. In this study we test whether functional maternal tolerance of male fetuses is critically dependent on the TH-2 cytokine Interleukin 10 (IL-10). Normal and IL-10-deficient (10-KO) females were sensitized against H-Y by intraperitoneal injection of male spleen cells before mating with 10-KO males. Litters born to 10-KO females were of comparable size to those born to normal females of the same genetic background. The proportion of males per litter was not adversely affected by IL-10 deficiency. Taken together, our work and others suggest that IL-10 may not be critically important for maternal tolerance of the fetus and extends the evidence against the idea that successful mouse pregnancy depends on TH-2 deviation of the maternal immune system.