Functional segregation of ITD sensitivity in the inferior colliculus of decerebrate cats.
Functional segregation of ITD sensitivity in the inferior colliculus of decerebrate cats.
复制标题
去大脑猫下丘 ITD 敏感性的功能分离。
DOI：
10.1152/jn.00356.2002
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
May,BradfordJ
中科院分区：
文献类型：
--
作者：
Ramachandran,Ramnarayan;May,BradfordJ
去大脑可以在没有麻醉和下行传出影响的情况下研究下丘中央核（ICC）的单单位反应。当这一程序被应用到猫，三种神经反应类型（V，I和O）可以识别由不同的模式的兴奋和抑制在纯音频率响应地图。明确的反应地图功能与听觉脑干中的投射神经元的相似性导致了ICC反应类型来自不同来源的上升输入的提议，这些输入在中脑内保持功能隔离。这些假设的平行处理途径的存在的额外证据已经获得了在我们以前的调查的影响，耳间水平的差异，脑干病变，和药理学操作的生理分类单位。这项研究扩展了我们的表征的功能隔离的单个单元的活动在ICC通过调查如何敏感性耳间时间差（ITDs）相关的反应类型，在去大脑猫。这些实验的结果支持我们的并行处理模型的ICC连接的ITD敏感性的V型和I型单位的假定输入从内侧上级橄榄和外侧上级橄榄和显示，大多数O型单位缺乏系统的敏感性双耳的时间信息，大概是因为他们的主导上升输入来自弱双耳神经元耳蜗背核。
Decerebration allows single-unit responses in the central nucleus of the inferior colliculus (ICC) to be studied in the absence of anesthesia and descending efferent influences. When this procedure is applied to cats, three neural response types (V, I, and O) can be identified by distinct patterns of excitation and inhibition in pure-tone frequency-response maps. Similarities of the definitive response map features with those of projection neurons in the auditory brain stem have led to the proposal that the ICC response types are derived from different sources of ascending input that remain functionally segregated within the midbrain. Additional evidence for the existence of these hypothesized parallel processing pathways has been obtained in our previous investigations of the effects of interaural level differences, brain stem lesions, and pharmacological manipulations on physiologically classified units. This study extends our characterization of the functional segregation of single-unit activity in the ICC by investigating how sensitivity to interaural time differences (ITDs) is related to the response types that are observed in decerebrate cats. The results of these experiments support our parallel-processing model of the ICC by linking the ITD sensitivity of type V and I units to putative inputs from the medial superior olive and lateral superior olive and by showing that most type O units lack a systematic sensitivity to binaural temporal information presumably because their dominant ascending inputs arise from weakly binaural neurons in the dorsal cochlear nucleus.
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