Terminal latency index and modified F ratio in distinction of chronic demyelinating neuropathies
Terminal latency index and modified F ratio in distinction of chronic demyelinating neuropathies
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DOI：
10.1016/s1388-2457(01)00469-2
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发表时间：
2001-03-01
影响因子：
4.7
通讯作者：
Pouget, J
中科院分区：
文献类型：
--
作者：
Attarian, S;Azulay, JP;Pouget, J
目的：评价标准电生理指标对慢性脱髓鞘性多神经病变（CDP）的鉴别价值。方法：对19例慢性炎症性脱髓鞘性多神经病变（CIDP）患者、25例抗髓鞘相关糖蛋白/硫酸葡萄糖醛基副叶苷抗体（MAG/SGPG） CDP患者、13例1A型（CMT1A）患者和22例对照组进行上肢神经传导研究。用终末潜伏期指数（TLI）比较腕-鱼际肌段与手腕传导速度。采用修正F比（MFR）比较脊髓-肘关节段潜伏期与腕-鱼际肌段潜伏期。结果：与对照组相比，21例抗mag /SGPG CDP患者TLI降低，MFR降低或正常。16例CIDP患者MFR升高，而TLI正常或升高。在CMT1A中，TLI和MFR均处于正常范围。MFR作为CIDP支持发现的敏感性为84%，特异性为89%。TLI作为诊断抗mag /SGPG CDP的平均灵敏度为93%，特异性为90%。结论：TLI和MFR的结果有助于区分不同类型的CDP。CIDP组MFR显著升高，TLI无变化；抗mag /SGPG组CDP、TLI、MFR显著降低；在CMT1A中，TLI和MFR与对照组相比没有变化。(C) 2001爱思唯尔科学爱尔兰有限公司版权所有。
Objective: To evaluate indexes calculated from standard electrophysiological data in differentiating chronic demyelinating polyneuropathy (CDP).Methods: Nerve conduction study of upper limbs was investigated in 19 chronic inflammatory demyelinating polyneuropathy (CIDP) patients, 25 anti-myelin-associated glycoprotein/sulfated glucuronyl paragloboside antibodies (MAG/SGPG) CDP patients, 13 Charcot-Marie-Tooth disease type 1A (CMT1A) patients and 22 controls. Terminal latency index (TLI) was used to compare the wrist-to-thenar muscle segment with the elbow-to-wrist conduction velocity. Modified F ratio (MFR) was used to compare the spinal cord-to-elbow segment latency with that of the wrist-to-thenar muscle segment.Results: Compared with controls, TLI was decreased in 21 anti-MAG/SGPG CDP patients while MFR was either decreased or was normal. In 16 CIDP patients, MFR was increased while TLI was either normal or increased. In CMT1A both TLI and MFR were in normal ranges. The sensitivity of MFR as a supportive finding in CIDP was found to be 84% and its specificity 89%. The sensitivity of TLI as a mean of diagnosis of anti-MAG/SGPG CDP was found to be 93% and its specificity 90%.Conclusion: The results of TLI and MFR facilitates distinction between different types of CDP. In CIDP, MFR was significantly higher and TLI showed no change; in the anti-MAG/SGPG CDP, TLI and MFR were significantly lower; in CMT1A, TLI and MFR showed no change in comparison with the controls. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.