Differential motor and prefrontal cerebello-cortical network development: Evidence from multimodal neuroimaging.
Differential motor and prefrontal cerebello-cortical network development: Evidence from multimodal neuroimaging.
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DOI：
10.1016/j.neuroimage.2015.09.022
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发表时间：
2016-01-01
期刊：
影响因子：
5.7
通讯作者：
Mittal VA
中科院分区：
文献类型：
--
作者：
Bernard JA;Orr JM;Mittal VA
虽然我们对青春期和青年期小脑结构发育的理解已经扩大，但我们仍然缺乏对小脑网络在生命的这一关键部分的发育模式的了解。小脑后外侧区与认知和前额叶皮质相关的体积发育较慢，在成年期达到峰值体积，特别是与运动小叶V相比。我们预测，在青春期和青年期，小脑后外侧区的静息状态功能连接将显示出类似的发展模式。也就是说，我们预计随着时间的推移，第一脚和第二脚与皮层的连接会发生变化，但第五小叶的连接不会发生变化。此外，我们感兴趣的是小脑-丘脑-皮质白色物质的结构连接性变化如何与功能连接性变化相关。23名12至21岁的受试者在基线和12个月后接受了神经影像学扫描。在12个月内，小腿I和小腿II的功能网络显示出显著的连接性降低，尽管小叶V中没有差异。此外，这些功能连接性变化与相应小脑-丘脑-皮质白色物质束中白色物质结构完整性的增加相关。我们认为，这些功能网络的变化是由于后修剪前额叶皮层以及进一步发展的白色物质束连接这些大脑区域。
While our understanding of cerebellar structural development through adolescence and young adulthood has expanded, we still lack knowledge of the developmental patterns of cerebellar networks during this critical portion of the lifespan. Volume in lateral posterior cerebellar regions associated with cognition and the prefrontal cortex develops more slowly, reaching their peak volume in adulthood, particularly as compared to motor Lobule V. We predicted that resting state functional connectivity of the lateral posterior regions would show a similar pattern of development during adolescence and young adulthood. That is, we expected to see changes over time in Crus I and Crus II connectivity with the cortex, but no changes in Lobule V connectivity. Additionally, we were interested in how structural connectivity changes in cerebello-thalamo-cortical white matter are related to changes in functional connectivity. A sample of 23 individuals between 12 and 21 years old underwent neuroimaging scans at baseline and 12-months later. Functional networks of Crus I and Crus II showed significant connectivity decreases over 12-months, though there were no differences in Lobule V. Furthermore, these functional connectivity changes were correlated with increases in white matter structural integrity in the corresponding cerebello-thalamo-cortical white matter tract. We suggest that these functional network changes are due to both later pruning in the prefrontal cortex as well as further development of the white matter tracts linking these brain regions.