Intracellular calcium receptor mechanisms.
Intracellular calcium receptor mechanisms.
复制标题
细胞内钙受体机制。
DOI：
10.1093/oxfordjournals.bmb.a072155
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发表时间：
1986
影响因子：
6.7
通讯作者：
P. England
中科院分区：
文献类型：
--
作者：
P. England
细胞含有同源钙结合蛋白家族中的一个或多个，其充当将细胞内钙浓度的变化传递到适当的靶系统的传感器。这些蛋白质的分子量为 16-20 000，具有一个或多个钙结合位点，对钙的亲和力在微摩尔范围内。钙与这些位点的结合会引起蛋白质的构象变化，从而改变它们与靶蛋白的相互作用，通常会引起适当系统的激活。在某些情况下，这种相互作用可以通过其他第二信使，特别是环磷酸腺苷的作用来改变。此外，已知其他钙结合蛋白对于细胞内钙变化的反应也很重要。
Cells contain one or more of a family of homologous calcium binding proteins which act as transducers for relaying changes in intracellular calcium concentrations to the appropriate target systems. These proteins, of molecular weight 16–20 000, have one or more calcium binding sites which have an affinity for calcium in the micromolar range. Binding of calcium to theses sites causes conformational changes in the proteins which alter their interaction with the target proteins, normally causing activation of the appropriate system. In certain cases, this interaction can be modified by the action of other second messengers, particularly cyclic AMP. In addition, other calcium-binding proteins are known which are of importance in the response to changes in intracellular calcium.