Biomedical Nanomagnetics: A Spin Through Possibilities in Imaging, Diagnostics, and Therapy.
Biomedical Nanomagnetics: A Spin Through Possibilities in Imaging, Diagnostics, and Therapy.
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DOI：
10.1109/tmag.2010.2046907
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发表时间：
2010-07-01
影响因子：
2.1
通讯作者：
Krishnan KM
中科院分区：
文献类型：
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作者：
Krishnan KM
生物医学纳米磁学是科学、工程和医学的多学科研究领域，在成像、诊断和治疗方面具有广泛的应用。最近的发展提供了令人兴奋的可能性，在个性化医疗提供了一个真正的综合方法，结合化学，材料科学，物理学，工程学，生物学和医学，实施。在强调这一观点的同时，我们在此讨论该领域快速发展的重要问题，即，纳米尺度下的磁性行为，重点是弛豫动力学，纳米颗粒和核壳结构的合成和表面功能化，生物相容性和毒性研究，生物学约束和机会，以及体内和体外应用。具体来说，我们讨论了有针对性的药物输送和触发释放，新型造影剂的磁共振成像，癌症治疗使用磁流体热疗，体外诊断和新兴的磁粒子成像技术，这是定量和灵敏度足以与现有的成像方法竞争。此外，自组装的物理，这是生物学和纳米科学的未来发展的基础，说明与磁性纳米粒子。结果表明，各种竞争能量与自组装收敛在纳米长度尺度上，不同的组件可以通过改变颗粒的尺寸和尺寸分布进行定制。在本文中，虽然我们讨论了我们最近的研究，在广泛的背景下，多学科文献，我们希望弥合物理/化学/工程和生物/医学相关工作之间的差距，并在同一时间，目前在个别学科的基本概念。这种方法是必不可少的，因为生物医学纳米磁学进入下一阶段的创新转化研究，重点是定量体内成像，靶向和触发药物释放，图像引导治疗，包括验证交付和治疗反应的发展。
Biomedical nanomagnetics is a multidisciplinary area of research in science, engineering and medicine with broad applications in imaging, diagnostics and therapy. Recent developments offer exciting possibilities in personalized medicine provided a truly integrated approach, combining chemistry, materials science, physics, engineering, biology and medicine, is implemented. Emphasizing this perspective, here we address important issues for the rapid development of the field, i.e., magnetic behavior at the nanoscale with emphasis on the relaxation dynamics, synthesis and surface functionalization of nanoparticles and core-shell structures, biocompatibility and toxicity studies, biological constraints and opportunities, and in vivo and in vitro applications. Specifically, we discuss targeted drug delivery and triggered release, novel contrast agents for magnetic resonance imaging, cancer therapy using magnetic fluid hyperthermia, in vitro diagnostics and the emerging magnetic particle imaging technique, that is quantitative and sensitive enough to compete with established imaging methods. In addition, the physics of self-assembly, which is fundamental to both biology and the future development of nanoscience, is illustrated with magnetic nanoparticles. It is shown that various competing energies associated with self-assembly converge on the nanometer length scale and different assemblies can be tailored by varying particle size and size distribution. Throughout this paper, while we discuss our recent research in the broad context of the multidisciplinary literature, we hope to bridge the gap between related work in physics/chemistry/engineering and biology/medicine and, at the same time, present the essential concepts in the individual disciplines. This approach is essential as biomedical nanomagnetics moves into the next phase of innovative translational research with emphasis on development of quantitative in vivo imaging, targeted and triggered drug release, and image guided therapy including validation of delivery and therapy response.