Characterisation of human exposure pathways to perfluorinated compounds - Comparing exposure estimates with biomarkers of exposure
Characterisation of human exposure pathways to perfluorinated compounds - Comparing exposure estimates with biomarkers of exposure
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DOI：
10.1016/j.envint.2011.01.011
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发表时间：
2011-05-01
影响因子：
11.8
通讯作者：
Thomsen, Cathrine
中科院分区：
文献类型：
--
作者：
Haug, Line S.;Huber, Sandra;Thomsen, Cathrine
商业使用的全氟化合物和多氟化合物（PFCs）已在人体中广泛检测到，但人体接触的来源尚未完全确定。本研究的目的是评估一组挪威人中全氟化学品不同接触途径的相对重要性，并将估计摄入量与通过生物监测获得的内部剂量进行比较。使用室内空气和室内灰尘中的PFC浓度测量值以及来自食物频率问卷和挪威食物中PFC浓度的信息，对41名挪威妇女的研究组从多种接触源中的PFC摄入量进行了估计。食物通常是主要的接触源，根据不同的粉尘摄入率和“前体”化合物的生物转化系数，食物占全氟辛酸摄入总量中位数的67-84%，占全氟辛烷磺酸摄入总量中位数的88-99%。然而，就个人而言，室内环境占几名妇女总摄入量的50%左右。室内灰尘中PFCs的浓度与相应的血清浓度之间存在显著的正相关关系，这表明室内环境是PFCs的重要暴露途径。对于母乳喂养的婴儿来说，母乳被认为是迄今为止全氟化学品最重要的单一来源。通过比较使用PK模型计算的全氟辛酸和全氟辛烷磺酸血清浓度与血清中测量的相应浓度，确认了估计摄入量。尽管食物通常是全氟化学品的主要接触源，但室内环境也可能是人类接触全氟化学品的重要因素。本研究为PFCs的风险评估和控制策略提供了有价值的知识。(C)2011爱思唯尔有限公司保留所有权利。
Commercially used per- and polyfluorinated compounds (PFCs) have been widely detected in humans, but the sources of human exposure are not fully characterized. The objectives of this study were to assess the relative importance of different exposure pathways of PFCs in a group of Norwegians and compare estimated intakes with internal doses obtained through biomonitoring. Individual PFC intakes from multiple exposure sources for a study group of 41 Norwegian women were estimated using measured PFC concentrations in indoor air and house dust as well as information from food frequency questionnaires and PFC concentrations in Norwegian food. Food was generally the major exposure source, representing 67-84% of the median total intake for PFOA and 88-99% for PFOS using different dust ingestion rates and biotransformation factors of 'precursor' compounds. However, on an individual basis, the indoor environment accounted for up to around 50% of the total intake for several women. Significant positive associations between concentrations of PFCs in house dust and the corresponding serum concentrations underline the importance of indoor environment as an exposure pathway for PFCs. For breast-fed infants, breast milk was calculated to be the single most important source to PFCs by far. The estimated intakes were confirmed by comparing serum concentrations of PFOA and PFOS calculated using PK models, with the corresponding concentrations measured in serum. Even though food in general is the major source of exposure for PFCs, the indoor environment may be an important contributor to human exposure. This study provides valuable knowledge for risk assessment of PFCs and control strategies. (C) 2011 Elsevier Ltd. All rights reserved.