Total parathyroidectomy reduces elevated circulating fibroblast growth factor 23 in advanced secondary hyperparathyroidism
Total parathyroidectomy reduces elevated circulating fibroblast growth factor 23 in advanced secondary hyperparathyroidism
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DOI：
10.1053/j.ajkd.2004.05.026
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发表时间：
2004-09-01
影响因子：
13.2
通讯作者：
Fukagawa, M
中科院分区：
文献类型：
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作者：
Sato, T;Tominaga, Y;Fukagawa, M
背景：继发性甲状旁腺功能亢进是慢性肾脏病(CKD)5期患者常见的并发症，高磷血症加速CKD的发生。成纤维细胞生长因子23(成纤维细胞生长因子23)是一种磷调节蛋白，在几种磷酸盐消耗障碍中起着关键作用。本研究的目的是研究晚期继发性甲状旁腺功能亢进症与循环中的成纤维细胞生长因子-23水平之间的关系。方法：15例继发性甲状旁腺功能亢进症(甲状旁腺激素[PTH]，990+/-118pg/mL[ng/L])。均行甲状旁腺切除前臂自体移植(PTX)，用双抗体夹心酶联免疫吸附试验检测PTX前、后(第1、3、7、10天)大鼠血清中成纤维细胞生长因子-23(FGF23)的水平。结果术前血清成纤维细胞生长因子-23水平与血磷呈正相关(P
Background: Secondary hyperparathyroidism is a common complication inpatients with stage 5 chronic kidney disease (CKD), accelerated by hyperphosphatemia. Fibroblast growth factor 23 (FGF-23), a phosphorus-regulating protein, has key roles in several phosphate-wasting disorders. The aim of this study is to examine the association of advanced secondary hyperparathyroidism with circulating FGF-23 levels. Methods: Fifteen patients with marked secondary hyperparathyroidism (parathyroid hormone [PTH], 990+/-118 pg/mL [ng/L]) were enrolled. All underwent parathyroidectomy with forearm autotransplantation (PTX), and their FGF-23 levels were measured before and after PTX (days 1, 3, 7, and 10) by means of sandwich enzyme-linked immunosorbent assay. Results Preoperative FGF-23 levels correlated positively with phosphorus (P