Drug release behavior of electrospun twisted yarns as implantable medical devices
Drug release behavior of electrospun twisted yarns as implantable medical devices
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DOI：
10.1088/1758-5090/8/3/035019
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发表时间：
2016-09-01
期刊：
影响因子：
9
通讯作者：
Dijkstra, P. J.
中科院分区：
文献类型：
--
作者：
Maleki, H.;Gharehaghaji, A. A.;Dijkstra, P. J.
在这项研究中，使用基于两个带相反电荷的喷嘴的静电纺丝技术生产了加捻载药聚（L-丙交酯）（PLLA）和杂化聚（L-丙交酯）/聚（乙烯醇）（PLLA/PVA）纱线。通过将抗生素药物头孢唑啉添加到 PLLA 静电纺丝溶液中，将其掺入纱线纤维中。形态学研究表明，与捻度无关，形成均匀且光滑的纤维。纱线中电纺纤维的直径在较高捻度下减小，但产生的纱线直径较大。随着捻度的增加，纱线中纤维的结晶度增加。在头孢唑啉存在下，纤维直径、纱线直径和结晶度总是低于非载药纱线。此外，纱线机械性能显示药物负载后的强度、模量和断裂伸长率略低。捻度对 PLLA 和混合纱线中头孢唑啉体外释放行为的影响表明，两种类型的载药纱线具有相似的特征。然而，混合 PLLA/PVA 纱线释放的药物总量明显更高。 30 d 期间的释放动力学适合不同的数学模型。电纺 PLLA 纱线中头孢唑林的释放受扩散机制控制，最适合 Peppas 和 Higuchi 模型。最能描述混合 PLLA/PVA 纱线药物释放机制的模型是一阶模型和 Higuchi 模型。
In this study, twisted drug-loaded poly(L-lactide) (PLLA) and hybrid poly(L-lactide)/poly(vinyl alcohol) (PLLA/PVA) yarns were produced using an electrospinning technique based on two oppositely charged nozzles. Cefazolin, an antibiotic drug was incorporated in the yarn fibers by addition to the PLLA electrospinning solution. Morphological studies showed that independent of the twist rate, uniform and smooth fibers were formed. The diameter of the electrospun fibers in the yarns decreased at higher twist rates but produced yarns with larger diameters. At increasing twist rates the crystallinity of the fibers in the yarns increased. In the presence of cefazolin the fiber diameter, yarn diameter and crystallinity were always lower than in the non-drug loaded yarns. In addition the yarn mechanical properties revealed a slightly lower strength, modulus and elongation at break upon drug loading. The effect of the twist rate on the cefazolin in vitro release behavior from both PLLA and hybrid yarns revealed similar profiles for both types of drug-loaded yarns. However, the total amount of drug released from the hybrid PLLA/PVA yarns was significantly higher. The release kinetics over a period of 30 d were fitted to different mathematical models. Cefazolin release from electrospun PLLA yarns was governed by a diffusion mechanism and could best be fitted by Peppas and Higuchi models. The models that were found best to describe the drug release mechanism from the hybrid PLLA/PVA yarns were a first-order model and the Higuchi model.