FNIRS activity in the prefrontal cortex and motivational intensity: impact of working memory load, financial reward, and correlation-based signal improvement
FNIRS activity in the prefrontal cortex and motivational intensity: impact of working memory load, financial reward, and correlation-based signal improvement
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DOI：
10.1117/1.nph.5.3.035001
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发表时间：
2018-07-01
期刊：
影响因子：
5.3
通讯作者：
Kreplin, Ute
中科院分区：
文献类型：
--
作者：
Fairclough, Stephen H.;Burns, Christopher;Kreplin, Ute
先前的研究已经证明，前额叶皮质的神经血管激活的变化会增加工作记忆负荷。本研究的主要目的是在动机强度理论的框架内，利用功能近红外光谱(FNIRS)研究工作记忆容量的超负荷。第二个目标是探索基于相关性的信号改善(CBSI)作为校正系统变量影响的方法的影响。在第一项研究中，30名参与者(15名女性，平均年龄=21.09岁，S.D.=2.9年)在四种要求水平(容易、困难、非常困难和不可能)下完成了n-back工作记忆任务的口头版本。与原始数据相反，CBSI转换的fNIRS数据表明，当任务具有挑战性但有可能成功时，神经血管耦合在硬需求时最高。第二组30例，女性15例，平均年龄22.4岁。=5.3)重复了工作记忆的操作，增加了低水平和高水平的经济奖励。对CBSI转化的氧合(HBO)和脱氧(HHB)血红蛋白水平的分析重复了第一项在前额叶皮质右侧区域的研究(BA46)。在不可能要求参与者获得更高水平的经济奖励时，HHB_CBSI数据显著减少。这项研究首次使用神经血管数据支持动机强度模型的预测。此外，将CBSI应用于fNIRS数据可以提高HBO和Hbb对自变量的敏感性。(C)2018年光学仪器工程师学会(SPIE)
Previous research has demonstrated changes in neurovascular activation of the prefrontal cortex to increased working memory load. The primary purpose of the current paper was to investigate overload of working memory capacity using functional near-infrared spectroscopy (fNIRS) within the framework of motivational intensity theory. A secondary goal was to explore the influence of the correlation-based signal improvement (CBSI) as a method for correcting the influence of systemic variables. In study one, 30 participants (15 female, mean age = 21.09 years, s.d. = 2.9 years) performed a verbal version of the n-back working memory task under four levels of demand (easy, hard, very hard, and impossible). In contrast to the raw data, CBSI-transformed fNIRS data indicated that neurovascular coupling was highest at hard demand when the task was challenging but success was possible. The second study (N = 30; 15 female, mean age = 22.4 years, s.d. = 5.3) replicated the working memory manipulation with the addition of low versus high levels of financial reward. Analyses of CBSI-transformed levels of oxygenated (HbO) and deoxygenated (HHb) hemoglobin replicated the first study at right lateral regions of the prefrontal cortex (BA46). HHb_CBSI data were significantly reduced at impossible demand for participants receiving the higher level of financial reward. The study is the first to support predictions from the motivational intensity model using neurovascular data. In addition, the application of CBSI to fNIRS data was found to improve the sensitivity of HbO and Hbb to the independent variables. (c) 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)