14-3-3 modulation of the inflammatory response
14-3-3 modulation of the inflammatory response
复制标题
14-3-3 炎症反应的调节
DOI：
10.1016/j.phrs.2020.105236
复制
发表时间：
2021-01-17
影响因子：
9.3
通讯作者：
Perry, Matthew W. D.
中科院分区：
文献类型：
--
作者：
Munier, Claire C.;Ottmann, Christian;Perry, Matthew W. D.
炎症调节是免疫系统维持体内平衡的核心部分。已经显示对炎症过程具有影响的一类重要的调节蛋白是14-3-3蛋白。在此，我们描述了14-3-3在炎症反应调节中的作用。这些作用包括在遗传、分子和细胞水平上调节影响炎症的反应。在遗传水平上，14-3-3参与多种转录因子的调节，并影响免疫应答的关键效应物的转录。在分子水平上，炎症过程的许多组成部分，例如模式识别受体、蛋白酶激活受体和细胞因子通过14-3-3的磷酸化和识别来调节，同时已经观察到识别过程的破坏导致临床综合征。14-3-3还参与细胞增殖和分化的调节，这已显示影响免疫系统，特别是T细胞和B细胞。最后，我们讨论了14-3-3的异常水平如何导致不良的免疫反应和慢性炎症。
Regulation of inflammation is a central part of the maintenance of homeostasis by the immune system. One important class of regulatory protein that has been shown to have effects on the inflammatory process are the 14-3-3 proteins. Herein we describe the roles that have been identified for 14-3-3 in regulation of the inflammatory response. These roles encompass regulation of the response that affect inflammation at the genetic, molecular and cellular levels. At a genetic level 14-3-3 is involved in the regulation of multiple transcription factors and affects the transcription of key effectors of the immune response. At a molecular level many of the constituent parts of the inflammatory process, such as pattern recognition receptors, protease activated receptors and cytokines are regulated through phosphorylation and recognition by 14-3-3 whilst disruption of the recognition processes has been observed to result in clinical syndromes. 14-3-3 is also involved in the regulation of cell proliferation and differentiation, this has been shown to affect the immune system, particularly T- and B cells. Finally, we discuss how abnormal levels of 14-3-3 contribute to undesirable immune responses and chronic inflammatory conditions.