Cocaine decreases cortical cerebral blood flow but does not obscure regional activation in functional magnetic resonance imaging in human subjects
Cocaine decreases cortical cerebral blood flow but does not obscure regional activation in functional magnetic resonance imaging in human subjects
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DOI：
10.1097/00004647-199807000-00003
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发表时间：
1998-07-01
影响因子：
6.3
通讯作者：
Weisskoff, R
中科院分区：
文献类型：
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作者：
Gollub, RL;Breiter, HC;Weisskoff, R
作者使用功能性磁共振成像（fMRI）来确定急性静脉注射（IV）可卡因是否会改变全球脑血流量（CBF）或视觉刺激诱导的功能激活。他们在视觉刺激期间使用流量敏感交替反转恢复（FAIR）扫描序列来测量CBF和血氧水平依赖（BOLD）敏感T-2* 扫描序列，以测量可卡因和盐水输注前后的神经元激活。CO2（0.6 mg/kg IV，持续30秒）增加心率和平均血压，降低潮气末二氧化碳（CO2）。所有测量值均在2小时（输注间期）恢复至基线水平，且未受生理盐水影响。血流敏感性交替反转恢复成像显示，皮质灰质CBF在盐水输注后无变化（-2.4 +/-6.5%），但在可卡因输注后下降（-14.1 +/-8.5%）（n = 8，P < 0.01）。在白色物质中未检测到降低，也未发现将可卡因输注前即刻皮质灰质中的BOLD信号强度与输注后10分钟测量的BOLD信号强度进行比较的变化。视觉刺激导致在所有条件下（可卡因和生理盐水输注前后）视觉皮层中的BOLD信号增加。尽管一个小的（14%），但在全球皮质灰质CBF急性可卡因输注后显着下降，特定区域的BOLD成像，神经元介导的增加，可以可靠地测量。
The authors used functional magnetic resonance imaging (fMRI) to determine whether acute intravenous (IV) cocaine use would change global cerebral blood flow (CBF) or visual stimulation-induced functional activation. They used flow-sensitive alternating inversion recovery (FAIR) scan sequences to measure CBF and blood oxygen level-dependent (BOLD) sensitive T-2* scan sequences during visual stimulation to measure neuronal activation before and after cocaine and saline infusions. Cocaine (0.6 mg/kg IV over 30 seconds) increased heart rate and mean blood pressure and decreased end tidal carbon dioxide (CO2). All measures returned to baseline by 2 hours, the interinfusion interval, and were unchanged by saline. Flow-sensitive alternating inversion recovery imaging demonstrated that cortical gray matter CBF was unchanged after saline infusion (-2.4 +/- 6.5%) but decreased (-14.1 +/- 8.5%) after cocaine infusion (n = 8, P < 0.01). No decreases were detected in white matter, nor were changes found comparing BOLD signal intensity in cortical gray matter immediately before cocaine infusion with that measured 10 minutes after infusion. Visual stimulation resulted in comparable BOLD signal increases in visual cortex in all conditions (before and after cocaine and saline infusion). Despite a small (14%) but significant decrease in global cortical gray matter CBF after acute cocaine infusion, specific regional increases in BOLD imaging, mediated by neurons, can be measured reliably.