Sources of toxoplasma infection in pregnant women: European multicentre case-control study
Sources of toxoplasma infection in pregnant women: European multicentre case-control study
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DOI：
10.1136/bmj.321.7254.142
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发表时间：
2000-07-15
影响因子：
--
通讯作者：
Dunn, DT
中科院分区：
文献类型：
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作者：
Cook, AJC;Gilbert, RE;Dunn, DT
目的探讨妊娠期急性弓形虫病与食物和环境危险因素相关的优势比和人群归因分数。设计病例对照研究。研究地点：欧洲6个大城市。研究对象：经血清转换或抗弓形虫IgM阳性检测出急性感染的孕妇（例）与弓形虫血清阴性的孕妇进行比较主要结果测量急性感染的比值比，调整混杂变量;结果孕妇急性感染的最强预测危险因素是吃未煮熟的羊肉、牛肉或野味，接触土壤，到欧洲、美国和加拿大以外的地方旅行。与猫接触不是危险因素。30%和63%之间的感染，在不同的中心，归因于消费未煮熟或腌制肉制品和6%至17%的土壤contact.Conclusions未煮熟或腌制肉类是那不勒斯，意大利的主要危险因素，感染弓形虫在咨询所有中心。预防战略的目标应是减少儿科医生在肉类中的感染率，改善肉类研究所根据农业和加工方法的标签，并提高向孕妇提供的健康信息的质量和一致性。
Objective To determine the odds ratio and population attributable fraction associated with food and environmental risk factors for acute toxoplasmosis in pregnancy.Design Case-control study.Setting Six large European cities.Participants Pregnant women with acute infection (cases) detected by seroconversion or positive for anti-Toxoplasma gondii IgM were compared with pregnant women seronegative for toxoplasma (controls).Main outcome measures Odds ratios for acute infection adjusted for confounding variables; the population attributable fraction for risk factors.Results Risk factors most strongly predictive of acute infection in pregnant women were eating undercooked lamb, beef, or game, contact with soil, and travel outside Europe and the United States and Canada. Contact with cats was not a risk factor. Between 30% and 63% of infections in different centres were attributed to consumption of undercooked or cured meat products and 6% to 17% to soil contact.Conclusions Inadequately cooked or cured meat is Naples, Italy the main risk factor for infection with toxoplasma in consultant all centres. Preventive strategies should aim to reduce Paediatrician prevalence of infection in meat, improve labelling of Institute of meat according to farming and processing methods, and improve the quality and consistency of health information given to pregnant women.