Inertial separation in a contraction-expansion array microchannel
Inertial separation in a contraction-expansion array microchannel
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DOI：
10.1016/j.chroma.2010.11.081
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发表时间：
2011-07-08
影响因子：
4.1
通讯作者：
Park, Je-Kyun
中科院分区：
文献类型：
--
作者：
Lee, Myung Gwon;Choi, Sungyoung;Park, Je-Kyun
我们报告了一个收缩-膨胀阵列（CEA）微通道，允许惯性尺寸分离的惯性升力和迪恩阻力之间的力平衡的流体制度，其中惯性流体的影响变得显着。通道的横截面积的突然变化使流体流弯曲，并且与恒定横截面的弯曲微通道中的迪恩流相比产生类似的效果，从而引起作用在颗粒上的迪恩阻力。此外，颗粒在整个收缩区域受到惯性升力的影响。这两个力在整个CEA微通道中以彼此相反的方向作用，并且它们的力平衡决定了颗粒是否跟随迪恩流穿过通道。在这里，我们描述的CEA微流控装置的物理和设计，并证明完全分离的微粒（聚苯乙烯珠的4和10 μ m的直径）和有效的交换的载体介质，同时保留10 μ m的珠。(C)2010 Elsevier B. V.保留所有权利。
We report a contraction-expansion array (CEA) microchannel that allows inertial size separation by a force balance between inertial lift and Dean drag forces in fluid regimes in which inertial fluid effects become significant. An abrupt change of the cross-sectional area of the channel curves fluid streams and produces a similar effect compared to Dean flows in a curved microchannel of constant cross-section, thereby inducing Dean drag forces acting on particles. In addition, the particles are influenced by inertial lift forces throughout the contraction regions. These two forces act in opposite directions each other throughout the CEA microchannel, and their force balancing determines whether the particles cross the channel, following Dean flows. Here we describe the physics and design of the CEA microfluidic device, and demonstrate complete separation of microparticles (polystyrene beads of 4 and 10 mu m in diameter) and efficient exchange of the carrier medium while retaining 10 mu m beads. (C) 2010 Elsevier B.V. All rights reserved.