Use of a charged lidocaine derivative, tonicaine, for prolonged infiltration anesthesia.
Use of a charged lidocaine derivative, tonicaine, for prolonged infiltration anesthesia.
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使用带电利多卡因衍生物托尼卡因进行长时间浸润麻醉。
DOI：
10.1053/rapm.2002.28710
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发表时间：
2002
影响因子：
5.1
通讯作者：
Wang,GingKuo
中科院分区：
文献类型：
--
作者：
Khan,MohammedA;Gerner,Peter;Sudoh,Yukari;Wang,GingKuo
背景和目的：我们验证了一个假设，即永久性电荷化合物N-苯乙基利多卡因引起的皮肤麻醉持续时间（托卡因）将比其母体结构利多卡因引起的时间更长，并且其受肾上腺素（epi）的影响更小，在大鼠皮下注射后，方法在大鼠背部皮肤上分别皮下注射利多卡因和托卡因（0.1%或0.5%，每组n = 8），有和无epi（1：200，000）。皮肤干肌反射的抑制由一个盲观察者定量评价的次数针刺未能引起的伤害性运动反应的总数6针刺适用于injectedareas. ResultsDurationofcomplete伤害性阻滞在0.5%的托尼卡因和利多卡因组分别为619 ± 47和58 ± 2分钟;两组的完全恢复时间分别为1，106 ± 19和86 ± 3分钟。Epi使0.5%托卡因和利多卡因组的完全阻滞时间分别增加到750 ± 13和97 ± 11分钟，完全恢复时间分别增加到1，185 ± 13和172 ± 6分钟。皮肤毒性被认为只有在0.5%的托尼卡因与肾上腺素组（3的8只大鼠）。ConclusionsTonicaine是一种基本上更持久的局部麻醉剂与延迟起效的行动相比，利多卡因，并可能是有用的浸润阻滞的持续时间长的情况下，是可取的。
Background and ObjectivesWe tested the hypothesis that the duration of cutaneous anesthesia elicited by the permanently charged compoundN-phenylethyl lidocaine (tonicaine) would be longer than that elicited by its parent structure, lidocaine, and that it would be less affected by epinephrine (epi), after subcutaneous injection in rats, as a model for infiltration anesthesia.MethodsSubcutaneous injections were performed on the shaved dorsal skin of rats with either tonicaine or lidocaine (0.1% or 0.5%, n = 8 in each group) with and without epi (1:200,000). Inhibition of the cutaneous trunci muscle reflex was quantitatively evaluated by a blinded observer by the number of times pinpricks failed to elicit the nocifensive motor response out of a total of 6 pinpricks applied to the injected area.ResultsDuration of complete nociceptive blockade in the 0.5% tonicaine and lidocaine groups was 619 ± 47 and 58 ± 2 minutes, respectively; duration of full recovery in these groups was 1,106 ± 19 and 86 ± 3 minutes, respectively. Epi increased the duration of complete block in the 0.5% tonicaine and lidocaine groups to 750 ± 13 and 97 ± 11 minutes, respectively, and the duration of full recovery to 1,185 ± 13 and 172 ± 6 minutes, respectively. Skin toxicity was seen only in the 0.5% tonicaine with epi group (3 of 8 rats).ConclusionsTonicaine is a substantially longer lasting local anesthetic with a delayed onset of action compared with lidocaine and may be useful in situations where long duration of infiltration block is desirable.