SUICIDE ATTEMPTS, PLATELET MONOAMINE-OXIDASE AND AVERAGE EVOKED-RESPONSE
SUICIDE ATTEMPTS, PLATELET MONOAMINE-OXIDASE AND AVERAGE EVOKED-RESPONSE
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DOI：
10.1111/j.1600-0447.1977.tb06665.x
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发表时间：
1977-01-01
影响因子：
6.7
通讯作者：
MURPHY, DL
中科院分区：
文献类型：
--
作者：
BUCHSBAUM, MS;HAIER, RJ;MURPHY, DL
本文对79例非用药精神病患者和68名大学生志愿者的血小板单胺氧化酶活性(MAO)和平均诱发反应(AER)升高这两项生物学指标与自杀和自杀企图之间的关系进行了研究。在患者样本中，MAO低和AER增大的男性个体，这是一种以前与双相情感障碍相关的模式，与没有增加MAO的低MAO或高MAO患者相比，自杀企图的发生率显著增加。在正常志愿者组中，所有有自杀或自杀未遂家族史的男性低毛前驱都是AER扩大者。在低毛先证者的亲属中发现了四起完全自杀事件；没有高毛先证者的亲属自杀。低血小板MAO活性和AER增加的组合可能与精神疾病的遗传易感性有关。
The relationship between suicides and suicide attempts and 2 biological measures, platelet monoamine oxidase levels (MAO) and average evoked response (AER) augmenting, was examined in 79 off-medication psychiatric patients and in 68 college student volunteers chosen from the upper and lower deciles of MAO activity levels. In the patient sample, male individuals with low MAO and AER augmenting, a pattern previously associated with bipolar affective disorders, showed a significantly increased incidence of suicide attempts in comparison with either non-augmenting low MAO or high MAO patients. Within the normal volunteer group, all male low MAO probands with a family history of suicide or suicide attempts were AER augmenters themselves. Four completed suicides were found among relatives of low MAO probands; no high MAO proband had a relative who committed suicide. The combination of low platelet MAO activity and AER augmenting may be associated with a possible genetic vulnerability to psychiatric disorders.