Comparison of fluorodeoxyglucose uptake in symptomatic carotid artery and stable femoral artery plaques
Comparison of fluorodeoxyglucose uptake in symptomatic carotid artery and stable femoral artery plaques
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DOI：
10.1002/bjs.9403
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发表时间：
2014-03-01
影响因子：
9.6
通讯作者：
Brittenden, J.
中科院分区：
文献类型：
--
作者：
Shaikh, S.;Welch, A.;Brittenden, J.
背景资料：氟-18-标记的氟代脱氧葡萄糖（FDG）正电子发射断层扫描（PET）已被用于评估动脉粥样硬化斑块的代谢活性，并通过其被巨噬细胞摄取被认为具有识别易损斑块的潜力。目的是比较近期血栓栓塞性脑血管事件患者颈动脉斑块与腿部缺血患者股动脉斑块中FDG的摄取，并将FDG摄取与M1和M2巨噬细胞的比例相关联。有症状的颈动脉内膜切除术患者，严重的颈动脉狭窄和严重的腿部缺血和股总动脉严重狭窄的患者进行FDG-PET和组织学斑块分析。在感兴趣的区域中的最大活动的体素计算使用Patlak方法超过60分钟。斑块进行双重染色的CD 68，和M1和M2巨噬细胞subset.Results：有29颈动脉和25股动脉斑块的研究。颈动脉斑块的最大动态摄取与股动脉斑块相似：中位数（范围）分别为9.7（7.1-12.2）和10.0（7.4-16.6）（P = 0.281）。与股动脉斑块相比，颈动脉斑块中的CD 68巨噬细胞计数显著增加（分别为39.5（33.9-50.1）和11.5（7.7-21.3）; P < 0.001），M1促炎性巨噬细胞的比例也是如此。颈动脉狭窄程度与FDG最大动态摄取相关（r（s）= 0.48，P = 0.008）。他汀类药物治疗的患者。FDG摄取发生在显著动脉狭窄的区域，与炎症程度无关。
Background: Fluorine-18-labelled fluoroxdeoxyglucose (FDG) positron emission tomography (PET) has been used to evaluate atherosclerotic plaque metabolic activity, and through its uptake by macrophages is believed to have the potential to identify vulnerable plaques. The aims were to compare FDG uptake in carotid plaques from patients who had sustained a recent thromboembolic cerebrovascular event with that in femoral artery plaques from patients with leg ischaemia, and to correlate FDG uptake with the proportion of M1 and M2 macrophages present.Methods: Consecutive patients who had carotid endarterectomy for symptomatic, significant carotid stenosis and patients with severe leg ischaemia and significant stenosis of the common femoral artery underwent FDG-PET and histological plaque analysis. The voxel with the greatest activity in the region of interest was calculated using the Patlak method over 60 min. Plaques were dual-stained for CD68, and M1 and M2 macrophage subsets.Results: There were 29 carotid and 25 femoral artery plaques for study. The maximum dynamic uptake was similar in carotid compared with femoral plaques: median (range) 9.7 (7.1-12.2) versus 10.0 (7.4-16.6) respectively (P = 0.281). CD68 macrophage counts were significantly increased in carotid compared with femoral plaques (39.5 (33.9-50.1) versus 11.5 (7.7-21.3) respectively; P < 0.001), as was the proportion of M1 proinflammatory macrophages. The degree of carotid stenosis correlated with the maximum dynamic FDG uptake (r(s) = 0.48, P = 0.008).Conclusion: FDG uptake was no greater in symptomatic carotid plaques than in the less inflammatory femoral plaques. In patients on statin therapy. FDG uptake occurred in areas of significant arterial stenosis, irrespective of the degree of inflammation.