Evolutionary signals of selection on cognition from the great tit genome and methylome.
Evolutionary signals of selection on cognition from the great tit genome and methylome.
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DOI：
10.1038/ncomms10474
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发表时间：
2016-01-25
影响因子：
16.6
通讯作者：
Groenen MA
中科院分区：
文献类型：
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作者：
Laine VN;Gossmann TI;Schachtschneider KM;Garroway CJ;Madsen O;Verhoeven KJ;de Jager V;Megens HJ;Warren WC;Minx P;Crooijmans RP;Corcoran P;Great Tit HapMap Consortium;Sheldon BC;Slate J;Zeng K;van Oers K;Visser ME;Groenen MA
50多年来，大山雀（Parus Major）一直是进化、生态和行为研究的模式物种；特别是，学习和认知得到了深入研究。在这里，为了进一步了解这些重要性状背后的分子机制，我们从头组装了大山雀参考基因组，并对来自欧洲各地的另外 29 个个体进行了全基因组重新测序。我们发现，在正选择的区域中，与神经元功能、学习和认知相关的基因过多，并且这些区域的 CpG 甲基化增加。此外，大山雀神经元非 CpG 甲基化模式与在哺乳动物中观察到的非常相似，表明在神经元表观遗传调控中具有普遍作用，可以影响学习、记忆和经验诱导的可塑性。高质量的大山雀基因组组装将在进一步整合该模式物种的生态、进化、行为和基因组方法方面发挥重要作用。 大山雀（Parus Major）以其复杂的社会认知行为而闻名。在这里，作者对大山雀的基因组进行了测序，并显示了正选择区域中与学习和认知相关的基因，以及与在哺乳动物中观察到的类似的神经元非 CpG 甲基化模式。
For over 50 years, the great tit (Parus major) has been a model species for research in evolutionary, ecological and behavioural research; in particular, learning and cognition have been intensively studied. Here, to provide further insight into the molecular mechanisms behind these important traits, we de novo assemble a great tit reference genome and whole-genome re-sequence another 29 individuals from across Europe. We show an overrepresentation of genes related to neuronal functions, learning and cognition in regions under positive selection, as well as increased CpG methylation in these regions. In addition, great tit neuronal non-CpG methylation patterns are very similar to those observed in mammals, suggesting a universal role in neuronal epigenetic regulation which can affect learning-, memory- and experience-induced plasticity. The high-quality great tit genome assembly will play an instrumental role in furthering the integration of ecological, evolutionary, behavioural and genomic approaches in this model species. The great tit (Parus major) is known for its complex social-cognitive behaviour. Here, the authors sequence genomes of the great tit and show genes related to learning and cognition in regions under positive selection, as well as neuronal non-CpG methylation patterns similar to those observed in mammals.