Effects of exogenous carbon monoxide on radiation-induced bystander effect in zebrafish embryos in vivo
Effects of exogenous carbon monoxide on radiation-induced bystander effect in zebrafish embryos in vivo
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DOI：
10.1016/j.apradiso.2011.11.018
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发表时间：
2012-07-01
影响因子：
1.6
通讯作者：
Yu, K. N.
中科院分区：
文献类型：
--
作者：
Choi, V. W. Y.;Wong, M. Y. P.;Yu, K. N.
研究了低浓度外源性一氧化碳（CO）从三羰基氯甘氨酸合钌（CORM-3）中释放出来对斑马鱼胚胎间辐射诱导的旁观者效应（里贝）的影响。通过受精后25 h（hpf）胚胎上显示的凋亡信号的数量来评估里贝。观察到里贝以CO浓度依赖的方式诱导旁观者胚胎的凋亡显著减弱。(C)2011爱思唯尔有限公司保留所有权利。
In the present work, the influence of a low concentration of exogenous carbon monoxide (CO) liberated from tricarbonylchloro(glycinato)ruthenium (II) (CORM-3) on the radiation induced bystander effect (RIBE) in vivo between embryos of the zebrafish was studied. RIBE was assessed through the number of apoptotic signals revealed on embryos at 25 h post fertilization (hpf). A significant attenuation of apoptosis on the bystander embryos induced by RIBE in a CO concentration dependent manner was observed. (C) 2011 Elsevier Ltd. All rights reserved.