The reversibility of disuse osteoporosis
The reversibility of disuse osteoporosis
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废用性骨质疏松症的可逆性
DOI：
10.1007/bf02012784
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
S. Mattsson
中科院分区：
文献类型：
--
作者：
U. Lindgren;S. Mattsson
Sprague-Dawley菌株80只成年大鼠1只后腿固定9周后发生骨质疏松。测量水合骨密度和骨表面积时，股骨和胫骨均出现骨质疏松。在固定期后的10周内未观察到可逆性迹象。四环素和DCAF标记在再活动后10周内未能显示骨形成增加的明显迹象。在重组的那一刻以及之后的几周内，当以3h -胸腺嘧啶/DNA比率表达时，骨细胞有丝分裂活性有下降的迹象。结论是细胞增殖率和细胞活性的增加都不足以恢复废用性骨质疏松症。
One hind leg of 80 adult rats of the Sprague-Dawley strain was made osteoporotic by immobilization for 9 weeks. Osteoporosis was noted in both the femur and the tibia when the hydrated gross bone density and the bone surface areas were measured. No signs of reversibility were observed during 10 weeks after the period of immobilization. Tetracycline and DCAF labelling failed to show significant signs of increased bone formation during the 10 weeks after remobilization. At the moment of remobilization and for some weeks thereafter, there were signs of depressed mitotic activity in the bone cells when expressed as the3H-thymidine/DNA ratio. The conclusion was that neither the cell-proliferation rate nor the cellular activity increases sufficiently for restitution of the disuse osteoporosis.