A Study on the Basic Criteria for Selecting Heterogeneity Parameters of F18-FDG PET Images.
A Study on the Basic Criteria for Selecting Heterogeneity Parameters of F18-FDG PET Images.
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DOI：
10.1371/journal.pone.0164113
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Balkay L
中科院分区：
文献类型：
--
作者：
Forgacs A;Pall Jonsson H;Dahlbom M;Daver F;D DiFranco M;Opposits G;K Krizsan A;Garai I;Czernin J;Varga J;Tron L;Balkay L
纹理分析可能会给新的见解代谢活跃的肿瘤的定量表征。在以前的F18-FDG研究中，已经研究了30多个织构参数。本文的目的是宣布基本要求作为一种选择策略，以确定最合适的异质性参数来衡量纹理特征。我们预定义的要求是：可靠的异质性参数必须是体积独立的、可重复的，并且适合定量表达异质性程度。基于这个标准，我们比较了各种建议的同质性措施。使用常用的协议在三种不同的PET/CT扫描仪上测量均质圆柱体模。此外，放置在NEMA图像质量体模中的定制非均匀肿瘤插入物采用一组采集时间和几种不同的重建协议进行成像。回顾性分析65例肺部病变患者的PET数据。四个异质性参数的27个被认为是最有吸引力的，以表征纹理特性的代谢活性肿瘤的FDG PET图像。这四个参数包括熵、对比度、相关性和变异系数。这些参数与肿瘤体积（大于25-30 ml）无关，提供了可重复的值（相对标准偏差< 10%），并对异质性变化表现出高度敏感性。体模测量是一种可行的方法来测试核成像临床医生感兴趣的异质性参数的可靠性。
Textural analysis might give new insights into the quantitative characterization of metabolically active tumors. More than thirty textural parameters have been investigated in former F18-FDG studies already. The purpose of the paper is to declare basic requirements as a selection strategy to identify the most appropriate heterogeneity parameters to measure textural features. Our predefined requirements were: a reliable heterogeneity parameter has to be volume independent, reproducible, and suitable for expressing quantitatively the degree of heterogeneity. Based on this criteria, we compared various suggested measures of homogeneity. A homogeneous cylindrical phantom was measured on three different PET/CT scanners using the commonly used protocol. In addition, a custom-made inhomogeneous tumor insert placed into the NEMA image quality phantom was imaged with a set of acquisition times and several different reconstruction protocols. PET data of 65 patients with proven lung lesions were retrospectively analyzed as well. Four heterogeneity parameters out of 27 were found as the most attractive ones to characterize the textural properties of metabolically active tumors in FDG PET images. These four parameters included Entropy, Contrast, Correlation, and Coefficient of Variation. These parameters were independent of delineated tumor volume (bigger than 25–30 ml), provided reproducible values (relative standard deviation< 10%), and showed high sensitivity to changes in heterogeneity. Phantom measurements are a viable way to test the reliability of heterogeneity parameters that would be of interest to nuclear imaging clinicians.
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