Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke
Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke
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DOI：
10.1016/j.bbrc.2020.05.203
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发表时间：
2020-07-30
影响因子：
3.1
通讯作者：
Koh, Young Ho
中科院分区：
文献类型：
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作者：
Choi, Ji-Young;Lee, Hye-Kyung;Koh, Young Ho
2019冠状病毒病（COVID-19）是一种全球性大流行病。它在人类中的传播率很高，对全球公共卫生构成威胁。然而，没有有效的药理学或治疗学可用。有必要查明易受伤害和易受感染的群体，以便对这一疾病提供充分的保护和照顾。最近的研究报告称，COVID-19以血管紧张素转换酶2（ACE 2）为功能性受体，可能导致具有糖尿病和吸烟等心血管疾病危险因素的患者发生严重的心血管疾病（CVD），包括中风。因此，世界卫生组织（WHO）建议吸烟者和有潜在临床症状（包括心血管疾病）的患者警惕COVID-19。本研究观察了大鼠大脑中动脉闭塞（MCAO）模型脑组织中ACE 2的表达，并评价了香烟烟雾提取物（CSE）和糖尿病对血管ACE 2表达的影响。我们发现，缺血损伤后，ACE 2的表达水平在皮质半暗带增加。CSE处理显著升高人脑血管中ACE 2的表达。我们发现与健康对照组相比，糖尿病患者的原代培养人血管中ACE 2表达上调。这项研究表明，ACE 2表达在缺血性大脑和暴露于糖尿病或吸烟的血管中增加，使它们容易受到COVID-19感染。(C)2020爱思唯尔公司All rights reserved.
Coronavirus disease 2019 (COVID-19) is a worldwide pandemic. It has a high transmission rate among humans, and is a threat to global public health. However, there are no effective prophylactics or therapeutics available. It is necessary to identify vulnerable and susceptible groups for adequate protection and care against this disease. Recent studies have reported that COVID-19 has angiotensin-converting enzyme 2 (ACE2) as a functional receptor, which may lead to the development of severe cerebrovascular diseases (CVD), including strokes, in patients with risk factors for CVD such as diabetes and smoking. Thus, theWorld Health Organization (WHO) advised caution against COVID-19 for smokers and patients with underlying clinical symptoms, including cardiovascular diseases. Here, we observed ACE2 expression in the brain of rat middle cerebral artery occlusion (MCAO) model and evaluated the effects of cigarette smoke extract (CSE) and diabetes on ACE2 expression in vessels. We showed that the levels of ACE2 expression was increased in the cortex penumbra after ischemic injuries. CSE treatment significantly elevated ACE2 expression in human brain vessels. We found that ACE2 expression was upregulated in primary cultured human blood vessels with diabetes compared to healthy controls. This study demonstrates that ACE2 expression is increased in ischemic brains and vessels exposed to diabetes or smoking, makes them vulnerable to COVID-19 infection. (C) 2020 Elsevier Inc. All rights reserved.