Pax2 contributes to inner ear patterning and optic nerve trajectory.
Pax2 contributes to inner ear patterning and optic nerve trajectory.
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DOI：
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发表时间：
1996-11
期刊：
影响因子：
4.6
通讯作者：
Miguel Torres;Emilia Gómez-Pardo;Peter Gruss
中科院分区：
文献类型：
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作者：
Miguel Torres;Emilia Gómez-Pardo;Peter Gruss
在妊娠期间，含有配对盒的基因Pax2在中脑区域、发育中的眼睛和内耳中表达。我们产生了Pax2无效突变小鼠，这表明Pax2的轴突通路的建立沿着视柄和腹侧间脑的要求。在突变的大脑中，由于视交叉发育不全，视束仍然完全同侧。此外，Pax2突变体显示色素视网膜延伸到视柄中，并且视裂未能闭合，导致缺损。在内耳中，Pax2突变体显示耳蜗和螺旋神经节发育不全，即，负责听觉功能的器官部分，其原基表达Pax2。我们的研究结果确定Pax2作为一个主要的调节器的图案在器官形成的眼睛和内耳，并表明其功能的形态发生事件所需的视裂和神经管的关闭。
During gestation, the paired box-containing gene Pax2 is expressed in the mid-hindbrain area, developing eye and inner ear. We generated Pax2 null mutant mice, which show the requirement of Pax2 for the establishment of axonal pathways along the optic stalks and ventral diencephalon. In mutant brains, the optic tracts remain totally ipsilateral due to agenesis of the optic chiasma. Furthermore, Pax2 mutants show extension of the pigmented retina into the optic stalks and failure of the optic fissure to close resulting in coloboma. In the inner ear, Pax2 mutants show agenesis of the cochlea and the spiral ganglion, i.e., the parts of the organ responsible for auditory function and in whose primordium Pax2 is expressed. Our results identify Pax2 as a major regulator of patterning during organogenesis of the eye and inner ear and indicate its function in morphogenetic events required for closure of the optic fissure and neural tube.