Bulk motion-independent analyses of water diffusion changes in the brain during the cardiac cycle
Bulk motion-independent analyses of water diffusion changes in the brain during the cardiac cycle
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DOI：
10.1007/s12194-009-0056-3
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发表时间：
2009-07-01
影响因子：
1.6
通讯作者：
Ichikawa, Katsuhiro
中科院分区：
文献类型：
--
作者：
Nakamura, Tomoya;Miyati, Tosiaki;Ichikawa, Katsuhiro
我们通过电影扩散MRI评估了心动周期期间大脑中水扩散的动态变化。在1.5 T MRI上，ECG触发的单次激发弥散回波平面成像与灵敏度编码、半扫描和矩形视野技术一起使用，以最大限度地减少体运动效应，如脑脉动，数据采样窗口为3 ms。表观扩散系数（ADC）和分数各向异性（FA）测定10名健康志愿者脑内白色区的颅内容积，并与心动周期内相位对比电影MRI显示的颅内容积变化（ICVC）进行比较。此外，对这些波形进行了频率分析。尽管可以最大限度地减少整体运动的影响，但ADC和FA值在心动周期期间发生显着变化，即，独立于整体运动。在心动周期内，ADC与ICVC同步。它们的振幅之间呈显著正相关。利用电影弥散MRI分析水弥散的动态变化有助于颅内情况的评估。
We evaluated dynamic changes in water diffusion in the brain during the cardiac cycle by using cine diffusion MRI. On a 1.5-T MRI, ECG-triggered single-shot diffusion echo planar imaging was used with sensitivity encoding, halfscan, and rectangular field of view techniques for minimizing bulk motion effects such as brain pulsation, with a data-sampling window of 3 ms. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in the white matter zone were determined in ten healthy volunteers and then compared with the intracranial volume change (ICVC) revealed by phasecontrast cine MRI during the cardiac cycle. In addition, a frequency analysis of these waveforms was performed. ADC and FA values changed significantly during the cardiac cycle, despite minimizing the effect of bulk motion, i.e., independent of bulk motion. The ADC was synchronized with the ICVC during the cardiac cycle. A significant positive correlation was noted among their amplitudes. Analysis of the dynamic change of water diffusion by use of cine diffusion MRI facilitates the assessment of intracranial conditions.