Secondary chromosomal abnormalities predict outcome in pediatric and adult high-stage Burkitt lymphoma
Secondary chromosomal abnormalities predict outcome in pediatric and adult high-stage Burkitt lymphoma
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DOI：
10.1002/cncr.22089
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发表时间：
2006-09-01
期刊：
影响因子：
6.2
通讯作者：
Sandlund, John T.
中科院分区：
文献类型：
--
作者：
Onciu, Mihaela;Schlette, Ellen;Sandlund, John T.
背景。散发性伯基特淋巴瘤（BL）的核型异常已被广泛报道。然而，据作者所知，非常有限的研究集中在儿童BL的继发性染色体异常与成人131的比较，以及它们对预后的影响。回顾性分析了2家机构的所有儿童和成人患者，有BL的形态学诊断，治疗前肿瘤核型，t(8;14), t（8;22）或t（2;8）存在。有33名儿童和37名成人。大多数患者（95%）为III/IV期疾病。两组患者核型复杂性及染色体异常性质差异无统计学意义。13 （13q）和22 （22q）染色体异常对儿童预后有负面影响。在成人中，17号染色体异常似乎有负面影响。目前的研究结果表明，核型信息可用于细化BL患者的风险分层。
BACKGROUND. Karyotypic abnormalities in sporadic Burkitt lymphoma (BL) have been described extensively. However, to the authors' knowledge, very limited studies have focused on the secondary chromosomal abnormalities in pediatric BL as compared with those of adult 131, and on their prognostic impact.METHODS. A retrospective analysis was performed in all pediatric and adult patients at 2 institutions, with a morphologic diagnosis of BL, pretherapy tumor karyotype available, and t(8;14), t(8;22), or t(2;8) present.RESULTS. There were 33 children and 37 adults. The majority of the patients (95%) had Stage III/IV disease. There were no statistically significant differences noted in karyotype complexity and the nature of the chromosomal abnormalities between these 2 groups. Abnormalities of chromosomes 13 (13q) and 22 (22q) had a negative impact on prognosis in children. In adults, abnormalities of chromosome 17 appeared to have a negative impact.CONCLUSIONS. The current findings suggest that karyotypic information can be used for refining risk stratification in patients with BL.