Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats
Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats
复制标题
DOI：
10.1111/j.1476-5381.2011.01499.x
复制
发表时间：
2011-12-01
影响因子：
7.3
通讯作者：
Yoshitake, T.
中科院分区：
文献类型：
--
作者：
Kehr, J.;Ichinose, F.;Yoshitake, T.
背景与目的1-(4-甲基苯基)-2-甲氨基丙烷-1-酮(4-甲基甲卡西酮，甲麻黄酮)是一种特制药物，据报道具有精神刺激、催眠和致幻作用。本研究的目的是观察急性给药对清醒大鼠伏隔核细胞外多巴胺(DA)和5-羟色胺(5-HT)水平的影响，并与3，4-亚甲基二氧甲基甲基苯丙胺(MDMA，摇头丸)和苯丙胺诱发的效应进行比较。
BACKGROUND AND PURPOSE The designer drug 1-(4-methylphenyl)-2-methylaminopropan-1-one (4-methylmethcathinone, mephedrone) is reported to possess psychostimulant, entactogenic and hallucinogenic effects. The purpose of this study was to examine the effects of acute administration of mephedrone on extracellular levels of dopamine (DA) and 5-HT in the nucleus accumbens of awake rats and compare these effects with those induced by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and amphetamine.