First trimester vaginal bleeding and adverse pregnancy outcomes among Chinese women: from a large cohort study in China
First trimester vaginal bleeding and adverse pregnancy outcomes among Chinese women: from a large cohort study in China
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中国女性妊娠早期阴道出血和不良妊娠结局：来自中国的一项大型队列研究
DOI：
10.3109/14767058.2011.632034
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发表时间：
2012-08-01
影响因子：
1.8
通讯作者：
Xu, Rong
中科院分区：
文献类型：
--
作者：
Sun, Lu;Tao, Fangbiao;Xu, Rong
目的：探讨妊娠早期阴道出血对早产、低出生体重儿、小于胎龄儿等不良妊娠结局的影响。方法：这是一项基于人群的前瞻性队列研究。由经过培训的医生对4342例独生子女进行问卷调查。用二元Logistic回归估计危险比(RR)和95%可信区间(95%CI)。结果：1050例孕妇发生阴道出血，阴道出血发生率为24.2%，未就诊的占37.4%，因阴道出血就诊的占62.6%。Logistic回归分析显示，就诊出血与早产显著相关(RR 1.84，95%CI 1.25~2.69)，未就诊出血与低出生体重儿增加显著相关(RR 2.52，95%CI 1.34~4.75)，是小于胎龄儿的1.97倍(RR 1.97，95%CI 1.19~3.25)。结论：这些结果表明，妊娠早期阴道出血增加了低出生体重、早产和小于胎龄的风险。寻找降低阴道出血风险和降低阴道出血率的方法可能有助于降低早产、低出生体重和小于胎龄的发生率。
Objectives: To examine the effect of first trimester vaginal bleeding on adverse pregnancy outcomes including preterm delivery, low birth weight and small for gestational age. Methods: This is a prospective population-based cohort study. A questionnaire survey was conducted on 4342 singleton pregnancies by trained doctors. Binary logistic regression was used to estimate risk ratios (RRs) and 95% confidence intervals (95% CI). Results: Vaginal bleeding occurred among 1050 pregnant women, the incidence of vaginal bleeding was 24.2%, 37.4% of whom didn’t see a doctor, 62.6% of whom saw a doctor for vaginal bleeding. Binary logistic regression demonstrated that bleeding with seeing a doctor was significantly associated with preterm birth (RR 1.84, 95% CI 1.25–2.69) and bleeding without seeing a doctor was related to increased of low birth weight (RR 2.52, 95% CI 1.34–4.75) and was 1.97-fold increased of small for gestational age (RR 1.97, 95% CI 1.19–3.25). Conclusions: These results suggest that first trimester vaginal bleeding is an increased risk of low birth weight, preterm delivery and small for gestational age. Find ways to reduce the risk of vaginal bleeding and lower vaginal bleeding rate may be helpful to reduce the incidence of preterm birth, low birth weight and small for gestational age.