Extracellular matrix molecules that influence neural development.
Extracellular matrix molecules that influence neural development.
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影响神经发育的细胞外基质分子。
DOI：
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发表时间：
1989
影响因子：
13.9
通讯作者：
J. Sanes
中科院分区：
文献类型：
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作者：
J. Sanes
随着发育中的神经元迁移、延伸轴突和形成突触，它们的许多行为都是特定的，也就是说，定型和可预测的。现在很清楚，内在神经元偏好并不能完全解释这种特异性，而是外在线索也影响神经元的选择。大约十年前，在几个系统中的实验开始暗示细胞外基质（ECM）作为这种指导的重要来源：与基质接触显示出影响神经元迁移、轴突生长和突触发生以及胶质细胞分化（Sanes 1983年综述）。一旦这些现象被记录下来，注意力就转向寻找介导它们的ECM分子。在这里，我总结了最近的工作。在审查非常新的和往往是初步的数据时，我试图指出一些正在出现的一般性主题，但避免从迅速发展的工作中得出预先的结论。在这个阶段，综合性比批判性似乎更有价值，尽管这排除了对构成神经细胞外基质分子分析基础的三个领域的考虑。首先，我引用了1983年以前发表的几篇论文，并请读者参阅早期的评论（Sanes 1983），以更详细地考虑以前的工作。第二，尽管神经系统中ECM的研究大多依赖于非神经细胞的早期研究，但我忽略了相关的背景知识。关于ECM的一般生物学和生物化学的最新综述包括Akiyama和Yamada（1987）、Buck和Horwitz（1987）、Cunningham（1987）、Hassell等（1986）、Hynes（1987）、Mayne和Burgeson（1987）、Martin和Timpl（1987）、Ruoslahti（1988）、Ruoslahti和Piersbacher（1987）、和
As developing neurons migrate, extend axons, and form synapses, much of their behavior is specific-that is, stereotypes and predictable. It is now clear that intrinsic neuronal predilections do not fully account for this specificity, but rather that extrinsic cues also influence neuronal choices. About ten years ago, experiments in several systems began to implicate the extracellular matrix (ECM) as an important source of this guidance: Contact with matrix was shown to influence neuronal migration, axonal growth, and synaptogenesis, as well as glial differentiation (reviewed in Sanes 1983). Once these phenomena had been documented, attention turned to a search for the ECM molecules that mediate them. Here, I summarize this recent work. In reviewing very new and often preliminary data, I have tried to indicate some general themes that are emerging, but to refrain from drawing prema ture conclusions from a rapidly evolving body of work. It has seemed, too, more valuable to be comprehensive than to be critical at this stage, even though this precludes consideration of three areas that form the back ground for molecular analysis of neural ECM. First, I have cited few papers published before 1983, and refer the reader to the earlier review (Sanes 1983) for more detailed consideration of previous work. Second, even though most work on ECM in the nervous system relies on earlier studies of nonneural cells, I have omitted this relevant background. Recent reviews on the general biology and biochemistry of ECM include those of Akiyama & Yamada (1987), Buck & Horwitz ( 1 987), Cunningham (1987), Hassell et al (1986), Hynes ( 1987), Mayne & Burgeson (1987), Martin & Timpl (1987), Ruoslahti ( 1 988), Ruoslahti & Piersbacher (1987), and