Nucleus basalis magnocellularis and attention: effects of muscimol infusions.
Nucleus basalis magnocellularis and attention: effects of muscimol infusions.
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大细胞基底核和注意：蝇蕈醇输注的影响。
DOI：
10.1037//0735-7044.107.6.1031
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发表时间：
1993
影响因子：
1.9
通讯作者：
Olton,DS
中科院分区：
文献类型：
--
作者：
Pang,K;Williams,MJ;Egeth,H;Olton,DS
雄性大鼠在孤束核（NTS）核上方植入插管尖端，接受训练以获取放置在 Y 形迷宫的 2 个臂中的食物颗粒，然后在迷宫的 1 个臂中进行足部电击。然后 Ss 接受双侧 NTS 注射利多卡因或缓冲液，并在外周注射盐水或肾上腺素（0.01 或 0.05 mg/kg，腹膜内 [ip]）。训练后 24 小时和 48 小时进行两项测试，以评估在存在和不存在与足部电击训练试验相关的情境线索（不锈钢地板）的情况下的记忆力。肾上腺素 (0.05 mg/kg) 可显着增强保留能力，但通过向 NTS 中注射利多卡因可减弱这种保留效果。这些发现表明 NTS 参与介导外周肾上腺素的记忆调节作用，并且这种作用至少部分是通过激活投射到 NTS 的迷走神经传入而引发的。（PsycINFO 数据库记录 (c) 2016 APA，保留所有权利）
Male rats implanted with cannula tips placed above the nucleus of the solitary tract (NTS) were trained to obtain food pellets placed in 2 arms of a Y-maze and then given a footshock in 1 arm of the maze. Ss then received bilateral injections of lidocaine or buffer into the NTS and peripheral injections of saline or epinephrine (0.01 or 0.05 mg/kg, intraperitoneally [ip]). Two tests were given 24 and 48 hrs after training to assess retention in the presence and absence of contextual cues (the stainless steel floor) associated with the footshock training trial. Epinephrine (0.05 mg/kg) produced a significant enhancement in retention, which was attenuated by injections of lidocaine into the NTS. These findings indicate that the NTS is involved in mediating the memory-modulating effects of peripheral epinephrine and that such effects are initiated at least in part by activation of vagal afferents projecting to the NTS.(PsycINFO Database Record (c) 2016 APA, all rights reserved)