Consumption of dairy products and risk of Parkinson's disease
Consumption of dairy products and risk of Parkinson's disease
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DOI：
10.1093/aje/kwk089
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发表时间：
2007-05-01
影响因子：
5
通讯作者：
Ascherio, Alberto
中科院分区：
文献类型：
--
作者：
Chen, Honglei;O'Reilly, Ellis;Ascherio, Alberto
作者对来自美国癌症协会癌症预防研究11营养队列的57,689名男性和73,175名女性进行了前瞻性调查，调查了乳制品摄入量与帕金森病风险之间的关系。在随访期间（1992-2001年），共发现250名男性和138名女性患有帕金森病。乳制品消费与帕金森病的风险呈正相关：与最低摄入量的五分位数相比，相应的五分位数为1.4,1.4,1.4和1.6(95%置信区间（CI）： 1.1, 2.2；P代表趋势= 0.05)。在乳制品消费者中，男性和女性都发现了更高的风险，尽管女性的关联似乎是非线性的。所有前瞻性研究的荟萃分析证实，高乳制品摄入量的人患帕金森病的风险中等升高：对于极端摄入量类别，男女的相对风险为1.6 (95% CI: 1.3, 2.0)，男性为1.8 (95% CI: 1.4, 2.4)，女性为1.3 （95% CI: 0.8, 2.1）。这些数据表明，乳制品消费可能会增加患帕金森病的风险，尤其是男性。需要更多的研究来进一步检验这些发现并探索潜在的机制。
The authors prospectively investigated the association between intake of dairy products and risk of Parkinson's disease among 57,689 men and 73,175 women from the American Cancer Society's Cancer Prevention Study 11 Nutrition Cohort. A total of 250 men and 138 women with Parkinson's disease were identified during follow-up (1992-2001). Dairy product consumption was positively associated with risk of Parkinson's disease: Compared with the lowest intake quintile, the corresponding relative risks for quintiles 2-5 were 1.4, 1.4, 1.4, and 1.6 (95 percent confidence interval (CI): 1.1, 2.2; p for trend = 0.05). A higher risk among dairy product consumers was found in both men and women, although the association in women appeared nonlinear. Meta-analysis of all prospective studies confirmed a moderately elevated risk of Parkinson's disease among persons with high dairy product consumption: For extreme intake categories, relative risks were 1.6 (95 percent CI: 1.3, 2.0) for both sexes, 1.8 for men (95 percent CI: 1.4, 2.4), and 1.3 for women (95 percent CI: 0.8, 2.1). These data suggest that dairy consumption may increase the risk of Parkinson's disease, particularly in men. More studies are needed to further examine these findings and to explore underlying mechanisms.