Association of body mass index with cognitive function in elderly hypertensive Japanese
Association of body mass index with cognitive function in elderly hypertensive Japanese
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DOI：
10.1038/ajh.2008.157
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发表时间：
2008-06-01
影响因子：
3.2
通讯作者：
Kario, Kazuomi
中科院分区：
文献类型：
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作者：
Sakakura, Kenichi;Hoshide, Satoshi;Kario, Kazuomi
背景 由于据报道高血压、肥胖和消瘦与认知功能不良有关，因此高血压患者的肥胖或消瘦可能也与认知功能不良密切相关。 方法 我们招募了 184 名老年高血压患者，其中包括 93 名高龄（年龄 >= 80 岁）和 91 名较年轻的老年人（年龄 61-79 岁）受试者。对所有参与者进行简易精神状态检查（MMSE）和24小时动态血压监测（ABPM）。根据体重指数 (BMI) 四分位数，将患者分为瘦型、正常体质或肥胖型。比较各组之间认知功能不良、MMSE 总分和 MMSE 分项评分的患病率。 结果 在总研究人群和高龄患者中，各组之间认知功能不良、MMSE 总分和 MMSE 分项注意力/计算分值的患病率存在显着差异。多元逻辑回归模型显示，在总研究人群（比值比（OR）2.54，95%置信区间（CI）1.13-5.73，P=0.02）和高龄患者（OR 3.94，95% CI 1.31-11.82，P=0.01）中，瘦削是认知功能不良的重要决定因素。无论是在整个研究人群、高龄老人还是较年轻的老年人群体中，肥胖都不是一个显着的决定因素。结论虽然老年高血压患者的肥胖与认知功能差无关，但老年高血压患者的瘦削却与认知功能差相关，尤其是高龄患者。
BACKGROUND As hypertension, obesity, and leanness are reported to be associated with poor cognitive function, it is possible that obesity or leanness in hypertensive patients may also be associated strongly with poor cognitive function.METHODS We recruited 184 elderly hypertensive patients comprising 93 very elderly (aged >= 80 years) and 91 younger elderly (aged 61-79 years) subjects. A mini-mental state examination (MMSE) and 24-h ambulatory blood pressure monitoring (ABPM) were performed in all participants. Patients were classified as either lean, normal physique, or obese according to the body mass index (BMI) quartile. The prevalence of poor cognitive function, total MMSE score, and MMSE subscores were compared between the groups.RESULTS The prevalence of poor cognitive function, total MMSE score, and MMSE subscore attention/calculation were significantly different between the groups both in the total study population and in the very elderly patients. The multiple logistic regression model showed that leanness was a significant determinant of poor cognitive function in both the total study population (odds ratio (OR) 2.54, 95% confidence interval (CI) 1.13-5.73, P= 0.02) and the very elderly patients (OR 3.94,95% CI 1.31-11.82, P= 0.01). Obesity was not a significant determinant in either the total study population, very elderly, or younger elderly groups.CONCLUSION While obesity in hypertensive elderly patients was not associated with poor cognitive function, leanness in hypertensive elderly patients was, especially in the very elderly.