Lifetime course of eating disorders: design and validity testing of a new strategy to define the eating disorders phenotype
Lifetime course of eating disorders: design and validity testing of a new strategy to define the eating disorders phenotype
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DOI：
10.1017/s0033291708003292
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发表时间：
2009-01-01
影响因子：
6.9
通讯作者：
Treasure, J.
中科院分区：
文献类型：
--
作者：
Anderluh, M.;Tchanturia, K.;Treasure, J.
背景进食障碍的病因学研究将受益于进食障碍症状不稳定问题的解决方案。我们提出了一种方法来定义一个饮食失调表型的基础上回顾性评估终身饮食失调症状，以定义一个终身的疾病模式。我们进一步验证了这种方法，通过测试最常见的终身类别的差异，在特定的儿童性格特征的患病率。97名女性参与了本研究，其中35名目前诊断为限制性神经性厌食症，32名患有神经性厌食症的狂欢/净化亚型，30名患有神经性贪食症。受试者接受了一个新开发的EATATE终身诊断访谈的回顾性评估的终身过程中的进食障碍症状和儿童特征，反映了强迫性人格。这些数据说明了进食障碍诊断的广泛不稳定性。四个最常见的终身诊断类别被确定为显着不同的儿童特征的患病率。完美主义和僵化更常见于体重不足状态持续时间较长、严重食物限制发作时间较长、过度运动和暴饮暴食持续时间较短的群体。终生症状的评估可能会产生一个更准确的定义进食障碍表型。童年时期的强迫症特征可能会缓和产生较长时间体重不足状态的过程。这些发现可能对饮食失调的疾病分类学、治疗和未来的病因学研究具有重要意义。
Background. Aetiological studies of eating disorders would benefit from a solution to the problem of instability of eating disorder symptoms. We present an approach to defining an eating disorders phenotype based on the retrospective assessment of lifetime eating disorders symptoms to define a lifetime pattern of illness. We further validate this approach by testing the most common lifetime categories for differences in the prevalence of specific childhood personality traits.Method. Ninety-seven females participated in this study, 35 with a current diagnosis of restricting anorexia nervosa, 32 with binge/purging subtype of anorexia nervosa and 30 with bulimia nervosa. Subjects were interviewed by a newly developed EATATE Lifetime Diagnostic Interview for a retrospective assessment of the lifetime course of eating disorders symptoms and childhood traits reflecting obsessive-compulsive personality.Results. The data illustrate the extensive instability of the eating disorders diagnosis. Four most common lifetime diagnostic categories were identified that significantly differ in the prevalence of childhood traits. Perfectionism and rigidity were more common in groups with a longer duration of underweight status, longer episodes of severe food restriction, excessive exercising, and shorter duration of binge eating.Conclusions. The assessment of lifetime symptoms may produce a more accurate definition of the eating disorders phenotype. Obsessive-compulsive traits in childhood may moderate the course producing longer periods of underweight status. These findings may have important implications for nosology, treatment and future aetiological studies of eating disorders.