The prevalence, characteristics of and early life risk factors for eczema in 10-year-old children
The prevalence, characteristics of and early life risk factors for eczema in 10-year-old children
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DOI：
10.1034/j.1399-3038.2003.00036.x
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发表时间：
2003-06-01
影响因子：
4.4
通讯作者：
Arshad, SH
中科院分区：
文献类型：
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作者：
Kurukulaaratchy, R;Fenn, M;Arshad, SH
湿疹是一种常见的婴儿疾病，但其性质和程度在儿童后期仍不清楚。在一项全人群出生队列研究中(n=1456)，我们调查了10岁儿童中湿疹的患病率和特征。在这个年龄段，第1373名儿童(94%)完成了艾萨克问卷调查，1043名儿童(72%)完成了皮肤点刺试验，953名儿童(65%)完成了血清吸入性IgE抗体筛查。10岁时有湿疹的患病率为41.0%，现患湿疹的患病率为13.7%(既有瘙痒皮疹又有湿疹)。目前的大多数湿疹(71.0%)开始于4岁之前，但与10岁时的低发病率有关。在4岁诊断为湿疹的儿童中，56.3%的儿童在10岁时出现当前湿疹。特应性(皮肤试验阳性)和其他过敏状态与当前湿疹相关(p<；0.001)。目前湿疹的危险因素分析表明，特应性反应(p=0.01)、鼻炎(p=0.04)和食物过敏(p=0.01)以及母亲哮喘(p=0.03)在4年后具有独立意义。4岁时被诊断为鼻炎的患者成为持续性疾病的重要预测指标。湿疹不仅仅是一种短暂的婴儿疾病，而是10岁时的常见问题，通常反映出儿童早期的持续性疾病。遗传的特应性倾向是这种状态的主要危险因素。
Eczema is a common infantile disease but its nature and extent during later childhood remains unclear. In a whole-population birth cohort study (n = 1456) we examined prevalence and characteristics of eczema amongst 10-year-old children. At this age 1373 (94%) children completed ISAAC questionnaires, 1043 (72%) skin prick testing and 953 (65%) serum inhalant IgE antibody screening. At 10 years of age prevalence of eczema ever was 41.0% and for current eczema was 13.7% (combined current itchy rash and eczema ever). Most current eczema (71.0%) began before 4 years of age, but was associated with low morbidity at 10 years. Amongst children with diagnosed eczema at 4 years of age, 56.3% had current eczema at 10 years. Atopy (positive skin test) and other allergic states were associated with current eczema (p < 0.001). Risk factor analysis for current eczema identified independent significance for atopy (p = 0.01), rhinitis (p = 0.04) and food allergy (p = 0.01) at 4 years, plus maternal asthma (p = 0.03). Diagnosed rhinitis at 4 years emerged as a significant predictor of persistent disease. Eczema is not simply a transient infantile condition but a common problem at 10 years of age, often reflecting persistent disease from early childhood. Inherited predisposition towards atopy is the predominant risk factor for this state.